A Quantitative Structure – Activity Relationship (QSAR) analysis of cyclic urea-based Human Immunodeficiency Virus Type 1 was carried out on a set of cyclic urea-based (HIV-1) protease inhibitors. The stepwise multiple regression analysis and genetic algorithm were employed as the feature selection and model development methods. Modeling of the relationship between selected molecular descriptor...

Lakes are disproportionately important ecosystems for humanity, containing 77% of the liquid surface freshwater on Earth and comprising key contributors to global biodiversity. With an ever-growing human demand for water and increasing climate uncertainty, there is pressing need for improved understanding of the underlying patterns of natural variability of water resources and consideration of ...

Dopamine neurotransmission has been implicated in the modulation of many cognitive processes. Both rapid (phasic) and slower (tonic) changes in its extracellular concentration contribute to its complex actions. Fast in vivo electrochemical techniques can measure extracellular dopamine on a rapid time scale but without the selectivity afforded with slower techniques that use chemical separations...

In this paper, we propose a novel approach using a cyclic group to model the appearance change in an image sequence of an object rotated about an arbitrary axis (1DOF out-of-plane rotation). In the sequence, an image xj is followed by an image xj+1. We represent the relationship between images by a cyclic group as xj+1 = Gxj , and obtain the matrix G by real block diagonalization. Then, G to th...

PURPOSE As favorable outcomes from malignant brain tumors remain limited by poor survival and treatment-related toxicity, novel approaches to cure are essential. Previously, we identified the cyclic AMP phosphodiesterase-4 (PDE4) inhibitor Rolipram as a potent antitumor agent. Here, we investigate the role of PDE4 in brain tumors and examine the utility of PDE4 as a therapeutic target. EXPERI...

12-molybdophosphoric acid (pmo12) was encaged into hmor zeolite by “ship in a bottle”method in aqueous phase which is strongly retained and not easily leached from the host channels.the solid was characterized by xrd prior to using it for the electrode preparation. this compoundwas incorporated with a carbon paste electrode for cyclic voltammetric measurements. pmo12immobilized on the support u...

objective: endothelium is a selective and permeable membrane for transferring nutrients and vital components to arterial wall. endothelial damage might lead to altered biological function of endothelium and clinical consequences such as atherosclerosis. blood pressure pulse always exerts circumferential tension to the arterial wall. hence, such tension together with other loads, play important ...

BACKGROUND/AIM To investigate the seasonal variations of the incidence of renal colic by a computerized analysis of cyclic climatic features. METHODS 1,163 consecutive patients with acute renal colic were studied. Eigendecomposition and signal reconstruction of district temperature and humidity were performed to establish any cyclic variation. Average temperatures and humidity values were cal...

Bayes nets (BNs) for relational databases are a major research topic in machine learning and artificial intelligence. When the database exhibits cyclic probabilistic dependencies, the usual Bayes net product formula does not define valid inferences. In this paper we describe and evaluate a new approach to defining Bayes net relational inference in the presence of cyclic dependencies. The key id...

In many manufacturing processes, process data are observed in the form of time-based profiles, which may contain rich information for process monitoring and fault diagnosis. Most approaches currently available in profile monitoring focus on single-stage processes or multistage processes with repeating cyclic profiles. However, a number of manufacturing operations are performed in multiple stage...