نتایج جستجو برای: cyclin a2

تعداد نتایج: 48839  

Journal: :Cancer research 2005
Karin Jirström Maria Stendahl Lisa Rydén Asa Kronblad Pär-Ola Bendahl Olle Stål Göran Landberg

Cyclins D1 and A2 are cell cycle regulators that also have the ability to interact with the estrogen receptor (ER) and consequently interfere with antiestrogen treatment in breast cancer. Experimental data support this concept, but the clinical relevance needs to be further established. In this study, we evaluated cyclin D1 and A2 protein expression by immunohistochemistry and cyclin D1 gene (C...

Journal: :Blood 2007
Shinichiro Koga Nobuhiro Yamaguchi Tomoko Abe Masayoshi Minegishi Shigeru Tsuchiya Masayuki Yamamoto Naoko Minegishi

In vitro manipulation of hematopoietic stem cells (HSCs) is a key issue in both transplantation therapy and regenerative medicine, and thus new methods are required to achieve HSC expansion with self-renewal. GATA2 is a transcription factor controlling pool size of HSCs. Of interest, continuous overexpression of GATA2 does not induce HSC proliferation. In this report, we demonstrate that GATA2 ...

Journal: :American journal of translational research 2013
Yongjun Li Shengda Hu Genshan Ma Yuyu Yao Gaoliang Yan Jia Chen Yefei Li Zhuoli Zhang

BACKGROUND Loss of cardiomyocytes after myocardial infarction (MI) causes heart failure. In this study, we investigate whether the in situ cardiomyocytes can re-enter the cell cycle and to what extent cell division of cardiomyocytes occurs after acute MI (AMI) in rats. METHODS Sprague Dawley (SD) rats were used in this study; the left anterior descending coronary artery was ligated. At time p...

Journal: :Oncology reports 2015
Hau-Lun Huang Wei-Ching Chen Hui-Ping Hsu Chien-Yu Cho Yu-Hsuan Hung Chih-Yang Wang Ming-Derg Lai

Arginine is a non-essential amino acid that modulates nitric oxide production and cancer homeostasis. In our previous study, we observed that blocking argininosuccinate lyase (ASL) attenuates tumor progression in liver cancer. However, the role of ASL in human breast cancer has been studied to a lesser degree. In the present study, we investigated the effect of targeting ASL in breast cancer. W...

Journal: :Molecular cancer therapeutics 2013
Hau-Lun Huang Hui-Ping Hsu Shu-Chu Shieh Yung-Sheng Chang Wei-Ching Chen Chien-Yu Cho Chiao-Fang Teng Ih-Jen Su Wen-Chun Hung Ming-Derg Lai

Arginine biosynthesis and nitric oxide (NO) production are important for cancer homeostasis. Degradation of arginine may be used to inhibit liver tumors with low argininosuccinate synthetase (ASS) expression. In this report, we investigated an alternative therapeutic approach by targeting argininosuccinate lyase (ASL). ASL is transcriptionally induced by endoplasmic reticulum stress and is over...

2017
Tingting Wu Jinyong Xu Shengchun Xu Lianzhong Wu Youyu Zhu Guangwu Li Zhenhua Ren

17β-Estradiol (E2) is a multifunctional steroid hormone in modulating metabolism in vivo. Previous studies have reported that E2 could promote insulin secretion and protect β cells from apoptosis. In this study, the partial pancreatectomy (PPx) model was used to study the role of E2 in islet cell proliferation. The animals were divided into four groups, including sham control, PPx model, E2, an...

2018
Luchao Chen Zhongxia Lu Yongle Yang Lijun Du Xiaofang Zhou Yitao Chen

Gastric cancer is one of the most common cancers globally with high rates of morbidity and mortality. Purified Omphalia lapidescens protein (pPeOp) is a protein extracted from the sclerotium of Omphalia lapidescens. The present study aimed to investigate the effects of pPeOp on the viability, migration, cell cycle progression and apoptosis of SGC-7901 cells. The expression of numerous proteins,...

Journal: :Journal of virology 2015
Shane C McAllister Ryan S Hanson Rory D Manion

Kaposi's sarcoma (KS) is common in Africa, but economic constraints hinder successful treatment in most patients. Propranolol, a generic β-adrenergic antagonist, decreased proliferation of KS-associated herpesvirus (KSHV)-infected cells. Downregulation of cyclin A2 and cyclin-dependent kinase 1 (CDK1) recapitulated this phenotype. Additionally, propranolol induced lytic gene expression in assoc...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید