Obese melanocortin-4-receptor-deficient (MC4R-/-) male mice are reported to have erectile dysfunction, while homozygous MC4R-/- female mice are apparently fertile. A recently established obese mouse strain, carrying an inactivating mutation in the MC4R gene, revealed difficulties in breeding for the homozygous female mice. This prompted us to determine the presence of follicles and corpora lute...

OBJECTIVE To describe the clinical symptoms associated with the diagnosis of pituitary gonadotroph adenoma in premenopausal women. DESIGN Report of three separate cases. SETTING University medical center. PATIENT(S) Three patients: a 31-year-old woman with primary infertility, recurrent adnexal masses, and highly elevated estradiol level; a 30-year-old woman with recurrent multicystic ova...

RATIONALE Leiomyomas arising from the anterolateral abdominal wall are uncommon, and their pathogenesis remains unknown. We present the 15th case of such a tumor, having this unique tumor morphology, followed by a detailed discussion on disease pathogenesis. PATIENT CONCERNS A 48-year-old, asymptomatic perimenopausal, multiparous Japanese woman presented with a left-sided pelvic mass. She had...

A seventy year old multiparus lady presented with progressive swelling in the abdomen. Clinical examination confirmed a large mass in the abdomin. The ultrasound showed a giant 35 cm abdomino-pelvic echogene mass, extending from the pubis symphysis to the epigastric region, displacing the liver, spleen and the urinary bladder. The computed tomography showed similar finding (figure 1). A giant o...

BACKGROUND Oocyte in vitro maturation (IVM) and cryopreservation at the time of routine ovarian tissue freezing may be offered to cancer patients as an additional option for fertility preservation. This study aimed to investigate the developmental capacity of oocytes isolated from unstimulated ovaries. METHODS Immature oocytes (n = 63) from seven consenting premenopausal patients were analyse...