The aim of the study was to identify a relationship between gene polymorphisms associated with developing coronary heart disease and pathogenetic features opisthorchiasis invasion. There were compared laboratory parameters assessing immune system functioning (lymphocyte immunophenotyping evaluated by flow cytometry, serum immunoglobulin cytokine concentrations, non-specific resistance indices) ...

study association with necrotising enterocolitis: genetic Cytokine gene polymorphisms in preterm infants service Email alerting the top right corner of the article Receive free email alerts when new articles cite this article-sign up in the box at

Colorectal cancer is the second-leading cause of cancer-related deaths in Europe and the United States (Parkin DM, 2001). Although the primary therapy of CRC is surgical, the elucidation of different novel prognostic markers may prove to serve as future therapeutic options and contribute to the overall understanding of this cancer entity, as well as to improver disease outcome. Inflammation has...

BACKGROUND Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chi...

Susceptibility to the autoimmune thyroid diseases, Graves' disease (GD) and autoimmune hypothyroidism (AIH), depends on a complex interaction between environmental and genetic factors. The human leukocyte antigen and cytotoxic T lymphocyte-associated-4 regions appear to influence susceptibility to disease, but the effect is not major, and the other genes remain unknown. Cytokines are crucial in...

CONTEXT Pro-inflammatory and regulatory cytokines play a key role in the pathogenesis of acute pancreatitis. Genetic loci encoding cytokines have been shown to be polymorphic, in some cases influencing protein expression. OBJECTIVE To investigate if TNF and IL-10 gene loci are associated with the occurrence or severity of acute pancreatitis. SETTING Acute surgical unit within large district...

Behçet's disease (BD) is a chronic, systemic disease, characterized by oral and genital lesions, and ocular inflammation. There is evidence indicating altered levels of proinflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) in patients with BD. This study involved 150 patients with BD and 140 healthy controls, and investigated the role of proinflammatory c...

Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of T-helper 2 cells. The aim if this study was to determine whether cytokine gene polymorphisms might influence the development of AD. Single nucleotide polymorphisms in the genes for I-L1alpha, IL-1beta, IL-1R, IL-2, IL-4, IL-6, IL-10, IL-12, TGF beta, TNF and IFNg...