objective(s) although, type 2 diabetes is the most frequent type of diabetes, its main cause is yet to be clarified. several environmental and genetic parameters are believed to be involved in diabetes. it has also been established that cytokines play key roles in pathogenesis of diabetes. expression of cytokines is different from person to person and in different societies. several studies sho...

Background: Recent clinical studies have reported that some cytokines are associated with lung cancer prognosis and mortality. However, the relationship between outcomes in severe patients was unclear. IL-6 as an important cytokine inflammation, expression level unknown.

Chronic kidney disease (CKD) is a global health problem associated with number of comorbidities. Recent evidence implicates increased hemichannel-mediated release adenosine triphosphate (ATP) in the progression tubulointerstitial fibrosis, main underlying pathology CKD. Here, we evaluate effect danegaptide on blocking changes expression and function proteins tubular epithelial cells. Primary hu...

Macrophages play a critical role in lung injury and repair processes. Their functions can be broadly classified into two polarized phenotypes. The M1 macrophages promote inflammation defense against pathogens, while the M2 are involved tissue resolution of inflammation. Gene manipulation techniques used to modulate macrophage polarization during injury. 1. Transcription factors: factors protein...

the study of cytokines gene expression is quite important in various conditions of health and disease for the evaluation of clinical responses to new vaccination approaches. an absolute quantification is based on a calibration curve and production of standard controls to achieve more reliable results than in relative system. in this study we attempted to construct standard controls to evaluate ...

background: ghrelin is a peptide with attenuating effect on inflammatory pain. both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. il-10 and tgf-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. in this study, the effects of i.p. injection ...

Background and Aims : Proprotein convertase subtilin/kexin type 9 (PCSK9) is a protease that gained importance in cardiovascular biology due to its regulatory action on the low-density-lipoprotein receptor (LDLR). However, PCSK9 can also act independent of LDLR cause vascular pathologies. We hypothesized affects expression chemokine-receptors CXCR4, CCR8, CCR5 CCR2 inflammatory cytokines, all m...

Abstract CD47 is a self-marker expressed on the surface of RBCs and work to prevent process phagocytosis. SIRPα ligand that phagocytic cells, such as macrophages, control removal dead/diseased cells. This study aimed examine expression PBMC cells in SCD patients apoptosis RBCs. We also measured levels pro-inflammatory cytokines correlated it with cell marker determine whether and/or played role...

Dermatomyositis (DM) is a chronic, systemic autoimmune disease affecting the skin, muscle, and lungs. The activation of CB2R has been shown to reduce several, key proinflammatory cytokines implicated in DM. Our group previously that expression was significantly increased DM skin compared blood, possibly due production local inflammatory cytokines. stimulation alleviates response by down-regulat...