Infection of mice with murine cytomegalovirus (MCMV) is an established model for studying human cytomegalovirus (HCMV) infection. Similarly to HCMV infection, pathological changes and disease manifestations during MCMV infection are mainly dependent on the immune status of the mouse host. This review focuses mainly on the pathogenesis of MCMV infection in immunocompetent and immunodeficient and...

Cytomegalovirus and Epstein-Barr virus infections remain one of the main concerns in the postoperative care of children with a liver transplantation. Most of the pediatric liver transplant recipients are seronegative for cytomegalovirus and/or Epstein-Barr virus at transplantation and this places them at marked risk for the development of cytomegalovirus/Epstein-Barr virus-related diseases. In ...

congenital cytomegalovirus infection. J. Infect. Dis. 209, 1573–1584. doi:10.1093/ infdis/jiu019 31. Williams, E.J. et al. (2013) Viral infections: contributions to late fetal death, stillbirth, and infant death. J. Pediatr. 163, 424–428. doi:10.1016/j.jpeds.2013. 02.004 32. Lorenzoni, F. et al. (2014) Neonatal screening for congenital cytomegalovirus infection in preterm and small for gestatio...

The neurodevelopmental state of 41 children with congenital cytomegalovirus infection and their controls was assessed at 2 years using the Griffiths scale. The scores achieved by children with congenital cytomegalovirus but with no associated neurological abnormality (asymptomatic) were similar to those of the control children, whereas the mean score of the five children with congenital infecti...

Cytomegalovirus (CMV) induced autophagy affects virus replication and survival of the infected cells. The purpose this study was to investigate role inhibition by 3-methyladenine (3-MA) on murine cytomegalovirus (MCMV) whether it is associated with caspase-3 dependent apoptosis. eyecup isolated from adult C57BL/6J mice (6–8 weeks old) mouse embryo fibroblast cells (MEFs) were MCMV K181 strain, ...

The typical radiographical findings of cytomegalovirus pneumonitis are bilateral interstitial infiltrates. In this study, the current authors describe two patients on corticosteroid treatment for systemic lupus erythematosus, complicated by histologically confirmed cytomegalovirus pneumonitis, presenting as cavitary masses. This rare presentation of cytomegalovirus pneumonitis broadens the diff...

Immunity mechanisms of cytomegalovirus infection control have been studied recently and have contributed to the better understanding of the pathogenesis of this disease in patients with a solid organ transplant. These studies suggest that a relationship exists between cytomegalovirus and the development of acute rejection. This relationship is more evident if the patient develops cytomegaloviru...

Cytomegalovirus retinitis is common in adults with AIDS but has been reported infrequently in children with perinatally acquired HIV infection. The cases are presented of two infants with vertically acquired HIV infection who developed disseminated cytomegalovirus infection and retinitis, and who posed difficult management issues.

McEnery, G., and Stern, H. (1970). Archives of Disease in Childhood, 45, 669. Cytomegalovirus infection in early infancy. Five cases of neonatal cytomegalovirus infection are described. None of them had the classical picture of neonatal cytomegalic inclusion disease. Two were cases of rhesus isoimmunization and two others were regarded initially as possible cases of ABO incompatibility. They we...

Cytomegalovirus infection is a common pathogen which rarely cause symptomatic disease in an immunocompetent patient. We present an immocompetent 55 year old male with complaints of pain abdomen and loss of appetite. Upper gastrointestinal endoscopy and radiologic features were suggestive of malignancy and partial gastrectomy was performed. Histopathologic findings were diagnostic of cytomegalov...