previous studies have indicated that some species of cuscuta possess anticancer activity on various cell lines. due to the lack of detailed researches on the cytotoxic effects of cuscuta chinensis and cuscuta epithymum , the aim of the present study was to evaluate cytotoxic effects of chloroform and hydroalcoholic extracts of these plants on the human breast carcinoma cell line (mda-mb-468), h...

sulfonamides are the first effective chemotherapeutic agents used for several years to cure or prevent systemic bacterial infections. in addition, this agents showed anti-carbonic anhydrase and cause cell cycle perturbation in the g1 phase, disruption of microtubule assembly, suppression of the transcription activator nf-y, angiogenesis and matrix metalloproteinase (mmp). in recent years, novel...

Background: Calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase II a key enzyme in apoptosis. In previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. In the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

Background and objectives: Due to the high cancer mortality rates and side effects of different types of cancer treatments, discovering effective treatments without or with fewer side effects is the main purpose of many researchers all around the world. Plants play an important role in the discovery of new drugs. Iran owns rich and varied vegetation but the majority of these pl...

Isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. It has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. Here branchlets and berries of Juniperus foetidissima and J. sabina were collected, dried and ethanol extracts of them obtain...

Isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. It has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. Here branchlets and berries of Juniperus foetidissima and J. sabina were collected, dried and ethanol extracts of them obtain...

in this study antibacterial, antifungal and cytotoxic effects of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives have been evaluated. the in vitro antibacterial and antifungal tests of new synthesized compounds were performed using maba method against six strains of bacteria (three gram-positive and three gram-negative) and three strains of fungi. also minimum bactericidal concentrat...

background and purpose: different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. unfortunately they don't always have desirable results and they may have unfavorable side effects. researchers try to find new, more effective drugs with low side effects. in this study we evaluated the cytotoxic effect of aca-1...

Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...

Background and objectives: Cancer is the third leading cause of mortality and morbidity in Iran and kills out about 30000 people a year. The drugs used to treat cancer have many side effects. So developing novel and effective drugs with lower side effects has a great importance. Located in the north-west of Iran, Ardebil province has a rich plant diversity which the biological ...