Atopic dermatitis (AD) and bullous pemphigoid (BP) are inflammatory skin diseases associated with intense pruritus significant quality of life (QOL) impact. While they differ in classical presentation (eczematous eruption vs urticaria blisters) population characteristics (young-to middle-aged persons elderly), early stages BP can appear similar to AD clinically histologically. As part this obse...

BACKGROUND Chronic pruritus is a global clinical problem with a high impact on the quality of life and lack of specific therapies. It is an excruciating and frequent symptom of e.g. uncurable renal, liver and skin diseases which often does not respond to conventional treatment with e.g. antihistamines. Therefore antipruritic therapies which target physiological mechanisms of pruritus need to be...

Bullous pemphigoid disease activity index (BPDAI) is the standard indicator of in bullous (BP). However, examining patients’ whole body burdensome to both patient and health care workers subjected inter-examiner bias, hence need investigate other surrogate markers for BPDAI. The purpose study quantify correlate candidate BP namely visual analogue scale pruritus (VAS-pruritus), thymus activation...

The most commonly used tool for self-report of pruritus intensity is the visual analogue scale (VAS). Similar tools are the numerical rating scale (NRS) and verbal rating scale (VRS). In the present study, initiated by the International Forum for the Study of Itch assessing reliability of these tools, 471 randomly selected patients with chronic itch (200 males, 271 females, mean age 58.44 years...

objective: we aimed to evaluate the efficacy of celecoxib in reducing intrathecal morphine-induced pruritus in parturient undergoing cesarean section delivery under spinal anesthesia. materials and methods: in a randomized double-blind placebo controlled study 126 women undergoing elective cesarean section under spinal anesthesia (0.5% bupivacaine 12mg plus 0.2 mg preservativefree morphine )wer...

Background Intractable pruritus in hemodialysis patients can significantly decrease their quality of life and is also associated with poor vital prognosis. Although combined multiple causes of intractable pruritus in these patients have been identified, no existing treatments are proven to be sufficiently effective. We conducted a post-marketing surveillance to follow-up and assess the safety a...

itching is one of the most common skin symptoms. generalized pruritus occurs in 1-8% of pregnant women. it can create unpleasant feeling for these women especially at nights. most pregnant women avoid using synthetic drugs because of their side effects. peppermint is a plant which has been used as a traditional drug in iran. it decreases skin’s temperature. this study was done to determine the ...