The wheat Green Revolution Rht-B1b and Rht-D1b dwarfing alleles are associated with increased grain yields but also reduced early growth seedling emergence, especially if sowing conditions unfavourable. gibberellic acid-responsive, mutagen-derived Rht18 gene was backcrossed from durum (Triticum turgidum subsp. L.) cv. Icaro into tall bread aestivum Halberd using phenotypic selection for plant h...

Single nucleotide polymorphisms (SNPs) in genes involved in thyroid hormone metabolism may affect thyroid hormone bioactivity. We investigated the occurrence and possible effects of SNPs in the deiodinases (D1-D3), the TSH receptor (TSHR), and the T(3) receptor beta (TR beta) genes. SNPs were identified in public databases or by sequencing of genomic DNA from 15 randomly selected subjects (30 a...

Mammalian cells contain different phospholipase D enzymes (PLDs) whose distinct physiological roles are poorly understood and whose products have not been characterized. The development of porcine aortic endothelial (PAE) cell lines able to overexpress PLD-1b or -2a under the control of an inducible promoter has enabled us to characterize both the substrate specificity and the phosphatidic acid...

Phospholipase D (PLD) activity can be detected in response to many agonists in most cell types; however, the pathway from receptor occupation to enzyme activation remains unclear. In vitro PLD1b activity is phosphatidylinositol 4,5-bisphosphate dependent via an N-terminal PH domain and is stimulated by Rho, ARF, and PKC family proteins, combinations of which cooperatively increase this activity...

The unprecedented wheat yield increases during the Green Revolution were achieved through introduction of Reduced height (Rht)-B1b and Rht-D1b semi-dwarfing alleles. These Rht-1 alleles encode growth-repressing DELLA genes containing a stop codon within their open reading frame that confers gibberellin (GA)-insensitive semi-dwarfism. In this study, we successfully took hurdle detecting wild-typ...

The central Keraf suture recorded complex lithospheric-scale deformation associated with the formation of Neoproterozoic Arabian-Nubian shield and hosts WG03, Central Zone UTM gold deposits, Gabgaba district, NE Sudan. This study aims at (i) unravelling tectonic history by (ii) interpreting spatial genetic relationships between structural setting mineralization. To this end, we coupled field pe...

BACKGROUND AND AIMS The gibberellin-insensitive Rht-B1b and Rht-D1b dwarfing genes are known to reduce the size of cells in culms, leaves and coleoptiles of wheat. Resulting leaf area development of gibberellin-insensitive wheats is poor compared to standard height (Rht-B1a and Rht-D1a) genotypes. Alternative dwarfing genes to Rht-B1b and Rht-D1b are available that reduce plant height, such as ...