Dopamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [373]) are commonly divided into D1-like (D1 and D5) D2-like (D2, D3 D4) families, where endogenous agonist is dopamine.

In this article, we obtain two sets of results. The first set results are for the case bi-disc while second describe in part, which these carry over to general poly-disc. A classification irreducible hermitian holomorphic vector bundles D2, homogeneous with respect Möb×Möb, is obtained assuming that associated representations multiplicity-free. Among ones give rise an operator Cowen-Douglas cla...

Dopaminergic transmission within limbic regions of the brain is highly dependent on the regulation of D2 receptor activity. Here we show that the neuronal calcium sensor-1 (NCS-1) can mediate desensitization of D2 dopamine receptors. Analysis of D2 receptors expressed in human embryonic kidney 293 cells indicates that NCS-1 attenuates agonist-induced receptor internalization via a mechanism tha...

Let I be the ideal generated by alternating polynomials in two sets of n variables. Haiman proved that the q, t-Catalan number is the Hilbert series of the bi-graded vector space M(= ⊕ d1,d2 Md1,d2) spanned by a minimal set of generators for I. In this paper we give simple upper bounds on dim Md1,d2 in terms of number of partitions, and find all bi-degrees (d1, d2) such that dimMd1,d2 achieve t...

A microphysiometer was used to quantify the rate of extracellular acidification by C6 glioma cells and L fibroblasts expressing recombinant dopamine D2 receptors. The dopamine D2 receptor agonist, quinpirole, accelerated the rate of acidification of the medium by C6 cells expressing either the short or long form of D2 receptors, D2(415) and D2(444), but not by wild-type cells that were not tran...

Mouse ovarian aryl hydrocarbon hydroxylase (AHH, EC 1.14.14.2) activity was measured in control mice and in DBA/ 2N (hereafter called D2) and C57BL/6N (hereafter called B6) mice treated with 3-methylcholanthrene (MC). Basal ovarian AHH activity was similar in both strains (3 pmol/mg/min). Ovarian AHH was induced 2to 3-fold in B6 mice after MC treatment, while no change was observed in similarly...

OBJECTIVE Higher latitude, lower ultraviolet exposure, and lower serum 25-hydroxyvitamin D (25OHD) correlate with higher multiple sclerosis (MS) prevalence, relapse rate, and mortality. We therefore evaluated the effects of high-dose vitamin D2 (D2) in MS. METHODS Adults with clinically active relapsing-remitting MS (RRMS) were randomized to 6 months' double-blind placebo-controlled high-dose...

The C3H/HeJ mouse presents an inherited type 1 deiodinase (D1) deficiency that results in elevated serum thyroxine (T(4)), whereas TSH and tri-iodothyronine (T(3)) concentrations are normal when compared with those in the C57BL/6J strain. Here, we evaluated the expression of the type 2 (D2), the other T(4)-activating enzyme, in C3H mice. A comparative analysis revealed that D2 mRNA levels in C3...

The distribution of mRNA coding for the D2 dopamine receptor was studied in the rat brain by in situ hybridization. A cDNA probe corresponding to the putative third cytosolic loop and sixth and seventh transmembrane domains of the rat D2 receptor was used to generate an 35S-labeled riboprobe to hybridize to D2 receptor mRNA. D2 mRNA was found both in dopamine projection fields and in regions as...

Let I be the ideal generated by alternating polynomials in two sets of n variables. Haiman proved that the q, t-Catalan number is the Hilbert series of the graded vector space M(= ⊕ d1,d2 Md1,d2) spanned by a minimal set of generators for I. In this paper we give simple upper bounds on dim Md1,d2 in terms of partition numbers, and find all bi-degrees (d1, d2) such that dimMd1,d2 achieve the upp...