Data warehousing hastens the process of retrieving information needed for decision making. The spider web diversity between both end-users and data marts increases traffic, load, and delay in accessing the requested information. In this research, we have developed a query dispatching tool facilitating the access to the information within data marts, eventually data warehouse in fast, and an org...

The problem of integrating autonomous data marts arises when, e.g., a large organization (or a federation thereof) needs to combine independently developed data warehouses. It turns out that this problem can be tackled in a systematic way because of two main reasons. First, data marts are usually structured in a rather uniform way, along dimensions and facts. Second, data quality in data marts ...

The Data Warehouse design involves the definition of structures that enable an efficient access to information. The designer builds a multidimensional structure taking into account the users requirements. In fact, it is a highly complex engineering task that calls for a methodological support. This paper lays the grounds for an automatic, stepwise approach for the generation of data warehouse a...

This paper discusses the application of the newly developed Mahalanobis distance-based ARTMAP (MART) network to the predication of sickle cell anemia patients’ response to Hydroxyurea treatment. Mahalanobis distance-based ARTMAP is a modified version of the Fuzzy ARTMAP networks where the activation and choice function are the same and equal to the Mahalanobis distance between the pattern and t...

This article examines the impact of Wal-Mart Supercenters’ entry on incumbents’ pricing behavior and demand. Using a structural model and milk data from the Dallas/Fort Worth supermarket chains, empirical results show that an expansion of Supercenters caused incumbents to price milk significantly more competitively, dropping on average 22.5% between 1996 and 2002, in spite of declines in their ...

Efficient processing of target antigens by the ubiquitin-proteasome-system (UPS) is essential for treatment of cancers by T cell therapies. However, immune escape due to altered expression of IFN-γ-inducible components of the antigen presentation machinery and consequent inefficient processing of HLA-dependent tumor epitopes can be one important reason for failure of such therapies. Here, we sh...

The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes. Recently, we described a case of severe neonatal alloimmune neutropenia (NAIN) caused by an alloantibody against a variant of the CD11b subunit (Mart alloantigen). Allele-specific transfected cells allowed us to demonstrate that an H61R point mutation is directly responsible for the formation of Mart epitopes. No diff...

Dendritic cells (DCs) are professional antigen-presenting cells that process and present antigenic peptides and are capable of generating potent T-cell immunity. A murine tumor model was developed to evaluate methods of genetic immunization to the human MART-1/Melan-A (MART-1) melanoma antigen. A poorly immunogenic murine fibrosarcoma line (NFSA) was stably transfected with the MART-1 gene. Thi...

BACKGROUND Translational research typically requires data abstracted from medical records as well as data collected specifically for research. Unfortunately, many data within electronic health records are represented as text that is not amenable to aggregation for analyses. We present a scalable open source SQL Server Integration Services package, called Regextractor, for including regular expr...

Data warehouses are in use for more than a decade but companies are still finding it difficult to decide on the approach they should take for successful implementation. Data warehouse architecture plays a major role the successful construction of data warehouse. This paper proposes an approach of constructing local data marts at source and integrating them at enterprise level by creating physic...