This paper presents an off-line integrated full ballast to supply a 35 W assembly of Power LEDs. The proposed solution integrates an input PFC stage (a flyback converter operating in DCM) and a DC-DC output converter (a buck converter) into a single switch power stage, operating with peak current control. As it will be shown, this control scheme maintains the current through the load constant, ...

Targeting antigen to dendritic cells (DCs) is a powerful and novel strategy for vaccination. Priming or loading DCs with antigen controls whether subsequent immunity will develop and hence whether effective vaccination can be achieved. The goal of our present work was to increase the potency of DC-based antitumor vaccines by overcoming inherent limitations associated with antigen stability and ...

Dendritic cells (DC) are the most potent APC in the organism. Immature dendritic cells (iDC) reside in the tissue where they capture pathogens whereas mature dendritic cells (mDC) are able to activate T cells in the lymph node. This dramatic functional change is mediated by an important genetic reprogramming. Glycosylation is the most common form of posttranslational modification of proteins an...

TNF family member CD70 is the ligand of CD27, a costimulatory receptor that shapes effector and memory T cell pools. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). We show here that, in addition, specific intracellular routing controls its plasma membrane dep...

Dendritic cells (DC) play essential roles determining efficacy of vaccine delivery with respect to immune defence development and regulation. This renders DCs important targets for vaccine delivery, particularly RNA vaccines. While delivery of interfering RNA oligonucleotides to the appropriate intracellular sites for RNA-interference has proven successful, the methodologies are identical for R...

Multiprotein complexes referred to as outer dynein arms (ODAs) develop the main mechanical force to generate the ciliary and flagellar beat. ODA defects are the most common cause of primary ciliary dyskinesia (PCD), a congenital disorder of ciliary beating, characterized by recurrent infections of the upper and lower airways, as well as by progressive lung failure and randomization of left-righ...

This paper presents the development of a high gain Boost converter applied to photovoltaic (PV) system. The converter was designed to be connected directly to the photovoltaic panel and perform the search for the maximum power point (MPPT). The new proposal seeks the MPPT is to connect each panel a converter for a high gain greater accuracy in finding the point of maximum power. The converter w...

Based on Generalized switchingcell approach, a generalized state-plane analysis for families of soft-switching dc-to-dc converters will be presented. It is shown the analysis of soft-switching dc-to-dc converter families can be analyzed in terms of simple two-dimensional state-plane diagram. Complete generalized design equations will also be given. It will be shown that one generalized transfor...

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell– specific transmembrane protein ...

DC-DC converters are switched power converters. They are used to convert one DC voltage to another DC voltage. It is inordinately used in industry as well as in research. The model of converter system varies from the ON state to the OFF state. The major drawback of the boost converter is the uncontrolled supply of voltage and current. So initially a convectional PID controller is designed to re...