Experimental models implicate protease activated receptors (PARs) as important sensors of the proteolytic tumor microenvironment during breast cancer development. However, the role of the major PARs, PAR-1 and PAR-2, in human breast tumors remains to be elucidated. Here, we have investigated how PAR-1 and PAR-2 protein expression correlate with established clinicopathological variables and pati...

BACKGROUND The poor prognosis of patients who experience ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS) is established. A short time between primary cancer and IBTR is a prognostic factor but no clinically relevant threshold was determined. Classification of IBTR may help tailor treatment strategies. PURPOSE We determined a specific time frame, which differen...

Numerical simulation reported on heat transfer and fluid flow in a two-dimensional rectangular micro channel totally filled with Ag/water. The first –order slip/jump boundary conditions were uniformly imposed to the up bottom walls. governing conservation equations are translated dimensionless form using thermal Single Relaxation Time (T-SRT) modified Lattice Boltzmann Method (LBM) double distr...

BackgroundThe identification of predictive biomarkers response to neoadjuvant chemotherapy (NACT) is an unmet need in early-stage TNBC. Transcriptomic classification according TNBCtype-4 classifier has shown value, and we aimed validate our previous results (Echavarria I et al, CCR 2018) terms long-term outcomes a larger cohort.MethodsStage I-III TNBC patients were enrolled across 10 hospitals ...

A, Turpeenniemi-Hujanen T: Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. elevated cyclooxygenase-2 expression in patients with adenocarcinoma of Lanschot JJB, Ristimäki A: Prognostic role of cyclooxygenase-2 expression in patients with squamous cell carcinoma of the esophagus. Int J Cancer, in press. The original publications are reprinted wit...

Much is known about the computation in individual neurons in the cortical column. Also, the selective connectivity between many cortical neuron types has been studied in great detail. However, due to the complexity of this microcircuitry its functional role within the cortical column remains a mystery. Some of the wiring behavior between neurons can be interpreted directly from their particular...

In this paper, an FPGA-based digital modulation signal generator with fading channel effect is presented for basic experimental usage. Instead of using off-the-shelf but costly instruments to test various communication systems, this FPGA-based signal generator is more cost-effective. We use Altera Stratix EP1S25 DSP development board as the hardware platform, which can be rapidly and flexibly r...

With the development of space technology and more and more space experiments, it has brought forward higher requests for memory of hard-recovered solid-state recorders. Therefore, Recovery of the memory becomes more important. Aiming at the disadvantages of present ways of recycling, we introduce a real-time GPS positioning wireless beacon which can be applied in memory recovery. This paper int...

A simple microprocessor controlled mini-electrochemical (EC) instrument integrating with square wave voltammetry (SWV) was designed nd fabricated. Direct digital frequency synthesizer (DDFS) was exploited in the circuit design to generate a linear and very low frequency canning waveform for SWV. An ultra-low bias current, a high performance operational amplifier, a lock-in amplifier, and severa...