نتایج جستجو برای: dectin

تعداد نتایج: 818  

Journal: :Journal of immunology 2008
Marcela Rosas Kate Liddiard Matti Kimberg Inês Faro-Trindade Jacqueline U McDonald David L Williams Gordon D Brown Philip R Taylor

Dectin-1 is the archetypal signaling, non-Toll-like pattern recognition receptor that plays a protective role in immune defense to Candida albicans as the major leukocyte receptor for beta-glucans. Dectin-1-deficiency is associated with impaired recruitment of inflammatory leukocytes and inflammatory mediator production at the site of infection. In this study, we have used mice to define the me...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009
Theo S Plantinga Walter J F M van der Velden Bart Ferwerda Annemiek B van Spriel Gosse Adema Ton Feuth J Peter Donnelly Gordon D Brown Bart-Jan Kullberg Nicole M A Blijlevens Mihai G Netea

Background. Intensive treatment of hematological malignancies with hematopoietic stem cell transplantation (HSCT) is accompanied by a high incidence of opportunistic invasive fungal infection, but individual risk varies significantly. Dectin-1, a C-type lectin that recognizes 1,3-beta-glucans from fungal pathogens, including Candida species, is involved in the initiation of the immune response ...

2013
Helen Rogers David W. Williams Gui-Jie Feng Michael A. O. Lewis Xiao-Qing Wei

Human infections involving yeast of the genus Candida often occur in the presence of bacteria, and, as such, it is important to understand how these bacteria influence innate host immunity towards Candida. Dectin-1 is a cell receptor of macrophages for Candida albicans recognition. The aim of this study was to examine dectin-1 expression by monocytes after stimulation with bacterial lipopolysac...

Journal: :Journal of immunology 2007
Helen S Goodridge Randi M Simmons David M Underhill

Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells and have elucidated some of the mechanisms by which Dectin-1 signals to coordinate the antifungal r...

2014
Yukihiro Kimura Kazuyasu Chihara Chisato Honjoh Kenji Takeuchi Shota Yamauchi Hatsumi Yoshiki Shigeharu Fujieda Kiyonao Sada

Dectin-1 recognizes β-glucan and plays important roles for the anti-fungal immunity through the activation of Syk in dendritic cells (DCs) or macrophages. Recently, expression of Dectin-1 was also identified in human and mouse mast cells, although its physiological roles were largely unknown. In this report, rat mast cell line RBL-2H3 was analyzed to investigate the molecular mechanism of Decti...

2017
Leilei Du Xu Chen Zhimin Duan Caixia Liu Rong Zeng Qing Chen Min Li

Dectin-1 is the critical sensor for β-glucan from Candida which is the most common human fungal pathogen and cause superficial and system infection. MicroRNAs (miRNAs) play crucial roles in regulating innate immunity. However, the functional role of miRNAs in inflammatory response dependent on the activation of dectin-1 pathway has not been defined. In the present study, we found insoluble β-gl...

Journal: :Glycobiology 2006
Eamon P McGreal Marcela Rosas Gordon D Brown Susanne Zamze Simon Y C Wong Siamon Gordon Luisa Martinez-Pomares Philip R Taylor

We examined the carbohydrate-binding potential of the C-type lectin-like receptor Dectin-2 (Clecf4n). The carbohydrate-recognition domain (CRD) of Dectin-2 exhibited cation-dependent mannose/fucose-like lectin activity, with an IC(50) for mannose of approximately 20 mM compared to an IC(50) of 1.5 mM for the macrophage mannose receptor when assayed by similar methodology. The extracellular doma...

2016
N Zahedi S Abedian Kenari S Mohseni N Aslani S Ansari H Badali

BACKGROUND AND PURPOSE Vulvovaginal candidiasis is a frequent disease affecting approximately more than %75 of all childbearing women at least once in their lifetime by overgrowth of opportunistic Candida species. Recurrent vulvovaginal candidiasis (RVVC) is common in otherwise healthy individuals. Several risk factors were reported to contribute to RVVC susceptibility. A polymorphism in Dectin...

2012
Susanne Sattler Hormas Ghadially Erhard Hofer

Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins. The human C-type lectin-like receptors encoded in the DECTIN-1 cluster within the NK gene complex contain prominent receptors with pattern recognition function, such as DECTIN-1 and LOX-1. All members of this c...

2018
Nicole Zimara Menberework Chanyalew Abraham Aseffa Ger van Zandbergen Bernd Lepenies Maximilian Schmid Richard Weiss Anne Rascle Anja Kathrin Wege Jonathan Jantsch Valentin Schatz Gordon D. Brown Uwe Ritter

Resistant mouse strains mount a protective T cell-mediated immune response upon infection with Leishmania (L.) parasites. Healing correlates with a T helper (Th) cell-type 1 response characterized by a pronounced IFN-γ production, while susceptibility is associated with an IL-4-dependent Th2-type response. It has been shown that dermal dendritic cells are crucial for inducing protective Th1-med...

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