نتایج جستجو برای: deep brain stimulation dbs

تعداد نتایج: 888101  

2012
Hamid R. Mohseni Penny P. Smith Christine E. Parsons Katherine S. Young Jonathan A. Hyam Alan Stein John F. Stein Alexander L. Green Tipu Z. Aziz Morten L. Kringelbach

Deep brain stimulation (DBS) has been shown to be clinically effective for some forms of treatment-resistant chronic pain, but the precise mechanisms of action are not well understood. Here, we present an analysis of magnetoencephalography (MEG) data from a patient with whole-body chronic pain, in order to investigate changes in neural activity induced by DBS for pain relief over both short- an...

2016
Le Dong

DISSERTATION Effects of deep brain stimulation (DBS) on microglia phenotype in rodent model of psychiatric disorder zur Erlangung des akademischen Grades Doctor medicinae (Dr.med.) 4.2.1 Electrode implantation per se can lead to an increase in the density and soma size of microglia in local brain region, which were normalized by DBS .. 4.4.2 mPFC-DBS treatment did not change the density of micr...

Journal: :Archives of neurology 2011
Jeff M Bronstein Michele Tagliati Ron L Alterman Andres M Lozano Jens Volkmann Alessandro Stefani Fay B Horak Michael S Okun Kelly D Foote Paul Krack Rajesh Pahwa Jaimie M Henderson Marwan I Hariz Roy A Bakay Ali Rezai William J Marks Elena Moro Jerrold L Vitek Frances M Weaver Robert E Gross Mahlon R DeLong

OBJECTIVE To provide recommendations to patients, physicians, and other health care providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD). DATA SOURCES AND STUDY SELECTION An international consortium of experts organized, reviewed the literature, and attended the workshop. Topics were introduced at the workshop, followed by group discussion. DATA EXTR...

Journal: :Neuroreport 2008
Merrill J Birdno Alexis M Kuncel Alan D Dorval Dennis A Turner Warren M Grill

The frequency of stimulation is one of the primary factors determining the effectiveness of deep brain stimulation (DBS) in relieving tremor. DBS efficacy, however, may depend not only on the average frequency of stimulation, but also on the temporal pattern of stimulation. We conducted intraoperative measurements of the effect of temporally irregular DBS (nonconstant interpulse intervals) on t...

Journal: :The Journal of neuropsychiatry and clinical neurosciences 2016
Alik S Widge Ernesto Licon Samuel Zorowitz Andrew Corse Amanda R Arulpragasam Joan A Camprodon Cristina Cusin Emad N Eskandar Thilo Deckersbach Darin D Dougherty

Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient regis...

Journal: :Brain Stimulation 2023

Abstract Objective: Since the development of new deep brain stimulation (DBS) devices in recent years, there is an increased need for assessing safety combination with transcranial magnetic (TMS). Methods: We applied a combined ex vivo and computational approach to investigate TMS using Boston Scientific segmented electrode. TMS-induced current was measured between electrode lead extension, dif...

2009
nne C. Smith Sudhin A. Shah Andrew E. Hudson Keith P. Purpura Jonathan D. Victor Nicholas D. Schiff

Deep brain stimulation (DBS) is an established therapy for Parkinson’s Disease and is being investigated as a treatment for chronic depression, obsessive compulsive disorder and for facilitating functional recovery of patients in minimally conscious states following brain injury. For all of these applications, quantitative assessments of the behavioral effects of DBS are crucial to determine wh...

Journal: :Trends in cognitive sciences 2013
Hweeling Lee Jürgen Fell Nikolai Axmacher

Deep brain stimulation (DBS) is a surgical procedure involving implantation of a pacemaker that sends electric impulses to specific brain regions. DBS has been applied in patients with Parkinson's disease, depression, and obsessive-compulsive disorder (among others), and more recently in patients with Alzheimer's disease to improve memory functions. Current DBS approaches are based on the conce...

2011
Vladan Novakovic Leo Sher Kyle A.B. Lapidus Janet Mindes Julia A.Golier Rachel Yehuda

Posttraumatic stress disorder (PTSD) is a complex, heterogeneous disorder that develops following trauma and often includes perceptual, cognitive, affective, physiological, and psychological features. PTSD is characterized by hyperarousal, intrusive thoughts, exaggerated startle response, flashbacks, nightmares, sleep disturbances, emotional numbness, and persistent avoidance of trauma-associat...

Journal: :Journal of neuroscience methods 2009
Nicholas T Vandehey P Charles Garell Joseph A Hampel Dhanabalan Murali Elizabeth M Smith Richard Davidson Alexander K Converse R Jerry Nickles Bradley T Christian

UNLABELLED PET imaging is a powerful tool for measuring physiological changes in the brain during deep brain stimulation (DBS). In this work, we acquired five PET scans using a highly selective D2/D3 dopamine antagonist, 18F-fallypride, to track changes in dopamine receptor availability, as measured by the distribution volume ratio (DVR), through the course of DBS in the bed nucleus of the stri...

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