PURPOSE VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors. EXPERIMENTAL DESIGN VNP40101M was given i.v. daily for 5 consecutive days every 6 weeks for up to eight cycles. Dose escalation was done independently in patients stratified based on intensity of prior therapy (moderately pretreated, stratum I; heavily pretr...

In certain animals, in addition to the protoplasmic fibrils of the stratum filamentosum that are present normally in human epidermis, there are well developed fibrils in the cells of the stratum germinativum. These fibrils are present in the human epidermis only under conditions of increased cell activity. These fibrils, that are prominent in the stratum germinativum of human epidermis under co...

In vivo water content in the epidermal stratum corneum can be estimated by means of low frequency susceptance measurements. In the in vitro calibration necessary to find the in vivo water content, the stratum corneum will have a uniform distribution of water across its thickness. However, in vivo stratum corneum has an increasing water concentration profile from the outermost towards the innerm...

Abstract Increasing drilling speed and efficiency of hard formation for deep ultra-deep well is one the international recognized problems key technologies to be tackled urgently. Particle jet impact technology an efficient non-contact rock-breaking method overcome slow speed, which has great development application potential in speed-increase well. High mechanism high temperature, pressure hard...

Given a random object on a stratified space embedded in a numerical space, often times the extrinsic sample means stick to a stratum that is closest to the population mean of the corresponding probability distribution in the ambient numerical space via this embedding. In the case of an open book, the limiting distribution of the extrinsic sample means supported on this possibly lower dimensiona...

This qualitative case-study explores the ways in which an innovative M.Ed. program facilitated the development of future ECE reflective leaders. Using case study methodology, it presents the transformational process two recent graduates underwent during their studies. The findings indicate four main sources that initiated the deep student reflection and introspection which influenced the develo...

Fluorescence recovery after photo-bleaching experiments were performed in human stratum corneum in vitro. Fluorescence multiphoton tomography was used, which allowed the dimensions of the photobleached volume to be at the micron scale and located fully within the lipid phase of the stratum corneum. Analysis of the fluorescence recovery data with simplified mathematical models yielded the diffus...

Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CAl of hippocampal slices was performed after (1) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-D-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 micr...

BACKGROUND The microscopic and microbial features of the spreading epidermal collarettes of canine exfoliative superficial pyodermas are poorly characterized. OBJECTIVES To characterize the clinical, cytological, microbial and histopathological features of epidermal collarettes in five dogs. RESULTS Cytology from the margins of collarettes identified neutrophils, extracellular and intracell...