Cerebral venous thrombosis (CVT) often affects young patients and can result in substantial disability and death. Though mortality rates among patients with CVT have declined, new epidemiological data suggests a higher annual incidence of CVT than previously reported. A diagnosis of CVT is associated with subsequent risk of venous thromboembolism, including deep vein thrombosis (DVT), pulmonary...

BACKGROUND Low-molecular-weight heparin (LMWH), because of its efficacy and ease of use, is an attractive alternative to unfractionated heparin in treatment and prophylaxis of venous thromboembolism. METHODS Using MEDLINE, I searched for relevant clinical trials using LMWH. I carefully reviewed these trials, allowing development of recommendations for use of LMWH in clinical practice. RESUL...

BACKGROUND Considerable variability exists in the use of pharmacological thromboprophylaxis among acutely ill medical patients, partly because clinically relevant end points have not been fully assessed in this population. We undertook an international, multicenter, randomized, double-blind, placebo-controlled trial using clinically important outcomes to assess the efficacy and safety of daltep...

A high plasma concentration of coagulation factor VIII (FVIII) is an important risk factor for venous thromboembolism (VTE) (1-4). In the Leiden Thrombophilia study for example, FVIII levels above 1500 IU/L conferred an almost 5-fold risk for a first episode of deep-vein thrombosis (1). Most importantly, high FVIII is also associated with a very high risk of recurrent venous thromboembolism (4,...

2112. 13. Lassen, M. R. (2000) The EPHESUS study: comparison of the first synthetic factor Xa inhibitor with low molecular weight heparin (LMWH). The prevention of venous thromboembolism (VTE) after elective hip replacement surgery. Blood 96(11), Abstract #2109. 14. Erickson, B. (2000) The PENTHIFRA study: comparison of the first synthetic Factor Xa inhibitor with low molecular weight heparin (...

OBJECTIVE  To determine the risk of venous thromboembolism associated with use of testosterone treatment in men, focusing particularly on the timing of the risk. DESIGN  Population based case-control study SETTING:  370 general practices in UK primary care with linked hospital discharge diagnoses and in-hospital procedures and information on all cause mortality. PARTICIPANTS  19 215 patient...

Pulmonary thromboembolism (PTE) is a major health problem with significant mortality and morbidity. It is a common and lethal condition. PTE and deep vein thrombosis (DVT) known collectively as venous thromboembolism (VTE) encompass one disease entity. Among cardiovascular diseases, VTE along with stroke and myocardial infarction rank as three big cardiovascular killers. PTE implies occlusion o...

BACKGROUND Up to one third of patients who undergo total knee replacement develop deep vein thrombosis after surgery despite receiving low-molecular-weight heparin prophylaxis. Ximelagatran is a novel direct inhibitor of free and clot-bound thrombin. METHODS We performed a randomized, parallel, dose-finding study of 600 adults undergoing elective total knee replacement at 68 North American ho...

The development of acute myeloid leukemia has been attributed to various factors, including hereditary, radiation, drugs, and certain occupational exposures. The association between malignancy and venous thromboembolism events is well established. Here, we present a case of a 70-year-old Indian man who had presented with arterial and venous thrombosis, and the patient was later diagnosed with a...