objective: dendritic cells (dcs) are essential for the activation and polarization of t cells during an adaptive immune response. in this research we investigated the effect of the lymphoide dcs pulsed with heat-treated tumor lysate (htl) as a vaccine in tumor immunotherapy. materials and methods: the balb/c mice were injected subcutaneously in the right flank with wehi-164 fibrosarcoma cells ...

At mucosal surfaces, immature resident Dendritic Cells, Langerhans Cells and their subsets are the first cell types to encounter HIV-1 virus. During early stages of infection, dendritic cells sense virus through innate immune mechanisms inducing maturation activating adaptive responses. subverts system by hijacking cells, impairing cellular function promote survival propagation trans-infection ...

Photosensitizer-free vaccination strategy can be accompanied by delivery of nanoadjuvants. B16F10 melanoma cells show a photothermal effect under irradiation near-infrared light. The nanoadjuvant, with imiquimod in amphiphilic peptide-based micelles, induces dendritic cell maturation. Near-infrared-irradiated and nanoadjuvant-treated group prevents lung metastasis B16F10. phototherapy peptide m...

The question about how intravenous anesthetic reagents affect the development and function of dendritic cell subsets still has no comprehensive answers. Bone marrow cells differentiated with FMS-like tyrosine kinase 3 ligand in vitro represented the steady-state dendritic cell subsets. The effects of ketamine on the generation and function of dendritic cell subsets were investigated. We found t...

The seed of Plantago asiatica L. is one of the most popular folk herbal medicines used in China and other Asian countries. In this study, phenylethanoid glycosides and polysaccharides were isolated from the seed of P.asiatica L. by using phytochemical investigation methods. A screening model of immunological activity by using dendritic cells as target cells was established to investigate the ef...

Abstract TARM1 is a member of the leukocyte immunoglobulin-like receptor family and stimulates macrophages neutrophils in vitro by associating with FcR?. However, function this molecule regulation immune system unclear. Here, we show that Tarm1 expression elevated joints rheumatoid arthritis mouse models, development collagen-induced (CIA) suppressed –/– mice. T cell priming against type 2 coll...

Dendritic cells are potent antigen-presenting cells endowed with the unique ability to initiate adaptive immune responses upon inflammation. Inflammatory processes are often associated with an increased production of serotonin, which operates by activating specific receptors. However, the functional role of serotonin receptors in regulation of dendritic cell functions is poorly understood. Here...

Objective(s): Chikungunya virus (ChikV) infection is characterized by persistent infection in joints and lymphoid organs. The ChikV Capsid protein plays an important role in regulating virus replication. In this study, we hypothesized that capsid protein may stimulate dendritic cell (DC) activation and maturation and trigger an inflammatory response in mice. ...