background: this study was done to test the notion that opium can reduce serum lipids and decrease the risk of ischemic heart disease (ihd) in opium addicts; we made a comparison between the lipid profiles of opium addicts and non-addicts.   methods: in this study, we compared 100 male opium addicts (according to the icd-10 criteria) who had referred to addiction treatment centers with 75 healt...

conclusions it can be concluded that tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes. it seems that antioxidants such as tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes. results the blood glucose level increased following diabetes induction. the level of blood glucose in the diabetic receiving tempol group decreased compared to the control d...

Background: The association between coronary artery disease and androgenic alopecia has been demonstrated, but few studies have focused on the mechanism of this association. The aim of this study was to evaluate the lipid profile in male pattern alopecia.Methods: In this case control study, 45 male patients with androgenic alopecia who were aged from 20 to 50 years and 45 men with a norma...

International clinical practice guidelines on dyslipidemia emphasize the importance of matching the use and intensity of statin therapy with the absolute risk of atherosclerotic cardiovascular disease (CVD). Indeed, independent of the baseline level of dyslipidemia, patients who have entered the intervention arms of randomized clinical trials of statin therapy with similar absolute risks of CVD...

Background: The superiority of TG/HDL-C and LDL-C/HDL-C ratios in predicting  CVD risk is a matter of debates. Thus, the objective of this study was to compare TG/HDL-C and LDL-C to HDL-C ratios in predicting the risk of CVD events. Methods: In a population-based cross-sectional study, 567 representative participants aged 40 years or older were entered in the study in Babol, North of Iran. The...

OBJECTIVE Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS Lipoprotein size and composition were measured by nuclear magnetic ...

Background: Diabetes is a prevalent chronic disease around the world. To evaluate risk of diabetes comprehensively, we developed a score model for the risk prediction with HDL-C as a protective factor. Methods: We extracted physical examination data of 2728 individuals. The data contain 18 demographic and clinical variables. To identify the statistical significant feature variables, the backwa...

Lipoprotein lipase (LPL), the rate-limiting enzyme for hydrolysis of plasma lipoprotein triglycerides, is a normal constituent of the arterial wall. We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). When bovine milk LPL was added to endothelial cell monolayers before addition of ...

HDLc, a cholesterol-rich lipoprotein that accumulates in the plasma of cholesterol-fed swine, was shown to resemble functionally human and swine low density lipoprotein in its ability to bind to the low density lipoprotein receptor in monolayers of cultured human fibroblasts. This binding occurred even though HDLc lacked detectable apoprotein B, which is the major protein of low density lipopro...