The association between users of combined oral contraceptives and depot-medroxyprogesterone acetate (DMPA) for contraception and bone mineral density (BMD) has been controversial because of variations among studies. Like other studies, this cross-sectional study compares BMD in users of combined oral contraceptives and DMPA with that in nonusers. Unlike previous studies, we defined long-term us...

background : irregular population growth is considered as a serious threat to the international community and is also a major obstacle for nations’ social and economic development. thus, one of the ways to have a healthy community is to control the population and provide safe and effective contraceptive methods. hormonal contraceptives are the most effective method of birth spacing. the present...

Preclinical HIV prevention models use either a single high-dose viral challenge in depot medroxyprogesterone acetate-treated macaques or repeated viral challenges in cycling macaques. We tested the efficacy of an intravaginal tenofovir disoproxil fumarate (TDF) ring in a model combining repeated 30-mg injections of depot medroxyprogesterone acetate every 6 weeks with vaginal viral challenges we...

INTRODUCTION HIV affects more women than any other life-threatening infectious agent, and most infections are sexually transmitted. HIV must breach the female genital tract mucosal barrier to establish systemic infection, and clinical studies indicate virus more easily evades this barrier in women using depot-medroxyprogesterone acetate (DMPA) and other injectable progestins for contraception. ...

BACKGROUND Abnormal uterine bleeding is commonly associated with progestin-only contraceptives, including depot medroxyprogesterone acetate (DMPA), and remains the main reason why these agents are discontinued. Matrix metalloproteinases (MMP), enzymes which degrade specific extracellular matrix components, and leukocytes are implicated in menstruation. Alteration in endometrial MMP-9 and leukoc...

This retrospective study looked at the bone mass density of women using combined oral contraception (n = 59), depot-medroxyprogesterone acetate (DMPA) (n = 34) or controls (n = 62) who had not used steroid contraception for 6 months. The groups were matched for body mass index, age, smoking, alcohol consumption, caffeine consumption and exercise. There was no matching for family history nor was...

Various synthetic progestogens that are used as contraceptives have been reported to influence lipid and lipoprotein fractions differently. Depo-medroxyprogesterone acetate (DMPA), a synthetic progestogen, is used by Nepalese women as a contraceptive agent. Our study aims to determine the effects of long-term use of DMPA on lipid metabolism. We performed this study on 60 healthy Nepalese women ...

This retrospective study looked at the bone mass density of women using combined oral contraception (n = 59), depot-medroxyprogesterone acetate (DMPA) (n = 34) or controls (n = 62) who had not used steroid contraception for 6 months. The groups were matched for body mass index, age, smoking, alcohol consumption, caffeine consumption and exercise. There was no matching for family history nor was...

BACKGROUND Depot medroxyprogesterone acetate contraception is widely used in Navajo women, a high-risk population for diabetes mellitus. However, depot medroxyprogesterone may lead to weight gain and independently decrease insulin sensitivity. We studied the association between depot medroxyprogesterone and development of diabetes in Navajo women. METHODS We studied Navajo women aged 18 to 50...

BACKGROUND In vitro, animal, biological and observational clinical studies suggest that some hormonal methods, particularly depot medroxyprogesterone acetate - DMPA, may increase women's risk of HIV acquisition. DMPA is the most common contraceptive used in many countries worst affected by the HIV epidemic. To provide robust evidence for contraceptive decision-making among women, clinicians and...