Construction of second derivative diagonally implicit multistage integration methods (SDIMSIMs) as a subclass general linear with Runge–Kutta stability property requires to generate the corresponding conditions depending parameters methods. These which are system polynomial equations can not be produced by symbolic manipulation packages for order p ≥ 5. In this paper, we describe an approach co...

We investigate the potential of applying a state-of-the-art, local derivative-free solver, Py-BOBYQA to global optimization problems. In particular, we demonstrate restarts procedure – as distinct from multistart methods allow escape minima (where ordinarily it would terminate at first minimum found). also introduce an adaptive variant which yields improved performance on As is model-based trus...

The aim of the present work was to develop a simple and rapid method for determination of theophylline (THP) and guaifenesin (GU) in syrup without involving any preparation operations like separation or masking. A HPLC and two spectrophotometric methods based on the derivation of the main spectra are described for the determination of THP and GU in combined pharmaceutical syrup form. The first ...

in this article, we survey the asymptotic stability analysis of fractional differential systems with the prabhakar fractional derivatives. we present the stability regions for these types of fractional differential systems. a brief comparison with the stability aspects of fractional differential systems in the sense of riemann-liouville fractional derivatives is also given.

background: chlorotoxin is a 36-amino acid peptide found in the venom of the leiurus quinquestriatus which blocks small-conductance chloride channels. chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. thus chlorotoxin derivative was labeled with 131i for further investigation. materials and methods:...