Both dermatophyte and non-dermatophyte fungi can colonise and invade the keratin of skin, nail and hair. The fungal morphological forms that adhere to these keratinaceous substrates are most probably arthroconidia and hyphal fragments in association with exfoliated corneocytes. Towards a greater understanding of the ability of fungi to utilise keratin we have developed a series of experimetal m...

Dermatomycoses due to Trichophyton violaceum are described in Mediterranean Countries, North Africa and in the Horn of Africa where T. soudanense is present too, but it was rare until few years ago in Italy. Aim of the present study was to evaluate an Italian multicenter 9 year (2005-2013) experience concerning these re-emerging pathogens. Fifty three fungal strains were sent from clinical labo...

Griseofulvin (GF) is a widely used antifungal drug for the treatment of superficial dermatomycoses. However, because GF is carcinogenic and teratogenic in animal models there is considerable concern regarding its clinical application. Further, it produces numerical chromosome aberrations in human lymphocytes and cell lines. There are conflicting reports on the ability of GF to induce structural...

Methods. Skin scrapings were taken from outpatients with superficial dermatomycoses and cultured in Sabouraud dextrose agar with cycloheximide. They were then evaluated under a microscope using both the KOH wet mount technique and the new contrast stain. Two investigators read the slides together but were blinded to all other test results. The new contrast stain contains 1% Chicago sky blue 6B ...

Systemic mycoses and their oral manifestations are very rare. We present a case of a 60-year-old man with an ulcerated lesion on the lateral border of the tongue. Histologic studies revealed a granulomatous fungal infection by Coccidioides immitis. After pharmacological treatment, the lesion resolved. Recently, northern Mexico has been reported to be an endemic zone of C. immitis infections; th...

Regional Hospital Pardubice, Department of Dermatology, Czech Republic Regional Hospital Pardubice, Department of Clinical Microbiology, Czech Republic Charles University in Prague, Faculty of Science, Department of Botany, Benátska 2, 128 01 Praha 2, Czech Republic; [email protected] Charles University in Prague, First Faculty of Medicine, Dermatological Clinic, Czech Republic *corresponding...

A case of dermatomycosis caused by zoophilic strain of Trichophyton interdigitale was treated by low-temperature plasma produced by direct current (DC) cometary discharge. The shortening of skin lesion persistence along with suppression of subjective discomfort and etiological agent was observed.

Fungal infection of bone by Penicillium marneffei is rare. We report on a case of Penicillium marneffei infection in a Filipino woman, which involved multiple soft-tissue abscesses and infection of the axial skeleton. Early diagnosis and treatment of this potentially reversible disease is emphasised. Such an approach is essential to prevent bony destruction from becoming too advanced and, more ...

pH governs most, if not all, processes of life. In fungi, ambient pH acts as a potent regulator of growth and development [1]. Studies conducted primarily in the 2 model organisms Saccharomyces cerevisiae and Aspergillus nidulans have cemented our understanding of how fungi sense and respond to pH. More recently, pH has emerged as a key player in the control of fungal pathogenicity. Infections ...