Portfolio optimization (selection) problem is an important and hard optimization problem that, with the addition of necessary realistic constraints, becomes computationally intractable. Nature-inspired metaheuristics are appropriate for solving such problems; however, literature review shows that there are very few applications of nature-inspired metaheuristics to portfolio optimization problem...

Optimum design of steel frames is a complicated process because the designer has to consider a large number of nonlinear constraints which are imposed by steel design codes while also dealing with discrete design variables. Obtaining the optimum solution to discrete programming problems was never easy until the emergence of metaheuristic techniques. The firefly algorithm, one of the recent meta...

OBJECTIVE The aim of this study was to determine the budget impact of everolimus (in combination with letrozole/anastrozole) as a second-line treatment for ER+ HER2- negative advanced and metastatic breast cancer in post-menopausal women. RESEARCH DESIGN AND METHODS A cumulative cohort model was developed to estimate the 5-year costs associated with introducing everolimus to the Kazakh health...

T his article, the last in this series, focuses on the lessons learned through our experience with participating in more than 20 replacement facility projects. It discusses the key elements that make such a project successful. First, a definition of “successful” is in order. A successful project is one that is not only completed on time and on budget but also results in improved market share, o...

Supplier selection and material procurement planning are the most important issues in supply chain management. This decision is complicated when the buyers face with discount price schemes. In real situation, each supplier may apply different methods such as different types of discount schedules and various types of payment in order to increase market share. In this situation, buyers try to sel...

4.1. OPERATIONAL APPROACHES ............................................................................... 10 4.1.1. Absolute temporal axis ................................................................................ 10 4.1.2. Script languages .......................................................................................... 11 4.1.3. Graphical Structures .............................

Advertising & promotion are an integral part of our social & economic system. An advertising decision is inclined by the choice of media, media effectiveness, media budget etc. especially if the advertising is required to be done in a segmented market. However, many of the decision making problems in the real world take place in an environment in which the goals, the constraints, and the conseq...

there are two major methods in predincing the pattern of share value in the stock market: fundamental analysis and technical analysis. i this study we developed a novel model for fundamental analysis of share price and validated it by predicting the behavior of phrama share price in tehran stock market. the efficiency of the fundamental method was compared with that of indicator-based technical...