An operationally simple one-pot, two-step procedure for the desymmetrization of benzils is herein described. This consists in the chemoselective cross-benzoin reaction of symmetrical benzils with aromatic aldehydes catalyzed by the methyl sulfinyl (dimsyl) anion, followed by microwave-assisted oxidation of the resulting benzoylated benzoins with nitrate, avoiding the costly isolation procedure....

An enantioselective alkoxylation/Claisen rearrangement reaction was achieved by a strategic desymmetrization of 1,4-dienes under the catalysis of (S)-DTBM-Segphos(AuCl)2/AgBF4. This reaction system was highly selective for the formation of 3,3-rearrangement products, providing cycloheptenes with various substitutions in good yield and good to excellent enantioselectivity. This transformation wa...

Three novel 19-nor-1α,25-dihydroxyvitamin D3 derivatives modified at C1 and/or C3 with an amino group were synthesized to study the influence of substitution one or both hydroxyl groups A-ring by on affinity for vitamin D receptor (VDR) and binding protein (hDBP), also antiproliferative activity. The precursors prepared from cis,cis-1,3,5-cyclohexanetriol applying a desymmetrization reaction pr...

This highlight review summarizes our recent studies of macrocyclic receptors with precise molecular recognition properties based on two concepts, assembly metal complex units, and desymmetrization components. The metallomacrocycles realized a unique binding by utilizing multipoint coordination rigidity the units. desymmetrized homooligomeric macrocycles achieved employing unsymmetrically arrang...