Recent studies in protein folding suggest that native state topology plays a dominant role in determining the folding mechanism, yet an analogous statement has not been made for RNA, most likely due to the strong coupling between the ionic environment and conformational energetics that make RNA folding more complex than protein folding. Applying a distributed computing architecture to sample ne...

Cell therapies require the in vitro expansion of adherent cells such as mesenchymal stromal cells (hMSCs) in bioreactor systems or other culture environments, followed by cell harvest. As hMSCs are strictly adherent cells, cell harvest requires cell detachment. The use of hMSCs for cell therapy requires GMP production in accordance with the guidelines for advanced therapeutic medical products. ...

PURPOSE To determine the risk of new retinal tear or detachment following cataract surgery in eyes that had undergone successful repair of phakic retinal tear or detachment. METHODS A computerized search of records of patients evaluated at the Barnes Retina Institute from 1990 to 2000 for a diagnosis of phakic retinal tear or detachment was accomplished. The records of successfully treated pa...

soil detachment is known as an important process in soil erosion and its quantification is necessary to establish a basic understanding of erosion. this study was carried out to find the best flow erosivity indicator(s) for predicting detachment rate at low slopes. for this purpose, 12 experiments including 6 flow discharges (75, 100, 125, 150, 175 and 200 ml/s) and 2 slope gradients (1.5 and 2...

PURPOSE To determine the retinal features seen on enhanced spectral-domain optical coherence tomography (SD-OCT) associated with foveal retinal detachment in eyes with myopic macular retinoschisis. DESIGN Retrospective case series. METHODS We reviewed fundus photographs and conventional and enhanced SD-OCT images of 21 eyes of 19 patients with myopic macular retinoschisis. Features seen on ...

Psychological detachment from work refers to the off-job experience of "switching off" mentally. It is hypothesized that a high degree of workload encountered during the work day has a negative impact on subsequent detachment processes and that psychological detachment from work is positively related to well-being. Eighty-seven individuals from various occupations provided questionnaire and dai...

Abstract This study focuses on two types of heavy work investment, namely workaholism and engagement, psychological detachment from work. Both engagement refer to an intense effort, yet with a different impact personal life. Building Stressor–Detachment Model (SDM), we examine how levels workaholism, influence outcomes related employees’ well-being (i.e., perceived health, negative affectivity,...

Prevention of microbial adhesion and detachment of adhering microorganisms from surfaces is important in many environmental, industrial, and medical applications. Fluid shear is an obvious parameter for stimulating microbial detachment from surfaces, but recently it has been pointed out that a passing air-liquid interface also has potential in stimulating microbial detachment. In the present st...