The multiple-trait derivative-free REML set of programs was written to handle partially missing data for multiple-trait analyses as well as single-trait models. Standard errors of genetic parameters were reported for univariate models and for multiple-trait analyses only when all traits were measured on animals with records. In addition to estimating (co)variance components for multiple-trait m...

The authors explore likelihood-based methods for making inferences about the components of variance in a general normal mixed linear model. In particular, they use local asymptotic approximations to construct confidence intervals for the components of variance when the components are close to the boundary of the parameter space. In the process, they explore the question of how to profile the re...

The widespread use of the set of multiple-trait derivative-free REML programs for prediction of breeding values and estimation of variance components has led to significant improvement in traits of economic importance. The initial version of this software package, however, was generally limited to pedigree-based relationships. With continued advances in genomic research and the increased availa...

In order to ascertain changes in bitterness as beer aged naturally, time±intensity (TI) measurements were made by a professional sensory panel using a squeezer transducer system. TI parameters were ®tted by variance components models using Restricted Maximum Likelihood (REML). It was shown that bitterness decreased with age, although this age-induced di€erence was smaller than the original di€e...

Six packages for solving mixed model equations and estimating variance components by REML are compared. Each has a unique strength. Meticulously finished DFREML is the only one that implements hypothesis testing for variance component estimates. MTDFREML is a comprehensive, relatively easy to install and simple to use package for analyses of experimental data. PEST, the only semi-commercial pro...

Subject Codes: 110 (congestive heart failure), 26 (exercise) df df df df df df dfie ie ie ie ie ie ield ld ld ld ld ld ABSTRACT Background: When advanced, heart failure (HF) with preserved ejection fraction (HFpEF) is

At the International Centre for Diarrhoeal Disease Research, Bangladesh, one-half of the rice-water stool samples that were culture-positive for Vibrio cholerae did not contain motile V. cholerae by standard darkfield microscopy and were defined as darkfield-negative (DF(-)). We evaluated the host and microbial factors associated with DF status, as well as the impact of DF status on transmissio...

INTRODUCTION Random regression (RR) models for longitudinal data often require a considerable number of parameters to describe the associated covariance functions. Estimation of these parameters has proven cumbersome and subject to sampling problems. Moreover, computational restraints have limited analyses of data sets sufficiently large to supply accurate estimates. This holds especially for c...