This was a prospective multicenter study aiming at comparing the efficiency of sperm selection by density gradient centrifugation (DGC) in reducing sperm DNA fragmentation (SDF) in different ART centers. The study was designed using 290 semen samples collected from 10 different ART centers performing artificial insemination, in vitro fertilization and blind assessment of SDF at the University f...

BACKGROUND Receptor tyrosine kinases promote tumor progression in many cancers, although oncologic activation differs between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC). Fibroblast growth factor receptor (FGFR) is one RTK, and we previously reported the clinical significance of FGFR1, 2, 3, and 4 in gastric cancer. The aim of the present study was to reevaluate t...

Many adult and diapausing pupal insects exchange respiratory gases discontinuously in a three-phase discontinuous gas exchange cycle (DGC). We summarize the known biophysical characteristics of the DGC and describe current research on the role of convection and diffusion in the DGC, emphasizing control of respiratory water loss. We summarize the main theories for the evolutionary genesis (or, a...

In modern web-based applications, an increasing amount of source code is generated dynamically at runtime. Web applications commonly execute dynamically generated code (DGC) emitted by third-party, black-box generators, run at remote sites. Web developers often need to adapt DGC before it can be executed: embedded HTML can be vulnerable to cross-site scripting attacks; an API may be incompatibl...

Gastric cancer is classified into two subtypes, diffuse and intestinal. The diffuse-type gastric cancer (DGC) has poorer prognosis, and the molecular pathology is not yet fully understood. The purpose of this study was to identify functional secreted molecules involved in DGC progression. We integrated the secretomics of six gastric cancer cell lines and gene expression analysis of gastric canc...

Recent discoveries suggest that a novel second messenger, bis-(3'-->5')-cyclic di-GMP (c-diGMP), is extensively used by bacteria to control multicellular behavior. Condensation of two GTP to the dinucleotide is catalyzed by the widely distributed diguanylate cyclase (DGC or GGDEF) domain that occurs in various combinations with sensory and/or regulatory modules. The crystal structure of the uno...

Earthworms native to the former mine site of Devon Great Consols (DGC), UK reside in soils highly contaminated with arsenic (As). These earthworms are considered to have developed a resistance to As toxicity. The mechanisms underlying this resistance however, remain unclear. In the present study, non-resistant, commercially sourced Lumbricus terrestris were exposed to a typical DGC soil in labo...

This article studies the potential combination of direct ground cooling (DGC) with district heating (DH) and source heat pumps (GSHP) to compare required borehole depths needed drilling areas. It also examines two different sizing approaches optimize investment costs The results show that in most cases are shorter for DGC DH than GSHP combination. is demonstrated optimal range outlet temperatur...

BACKGROUND The presentation of sepsis is varied and our hypotheses were that septic patients with non-specific presentations such as decreased general condition (DGC) have a less favourable outcome, and that a screening tool could increase identification of these patients. We aimed to: 1) assess time to antibiotics and in-hospital mortality among septic patients with ED chief complaint DGC, as ...

To demonstrate that selecting spermatozoa with the highest genomic integrity enhances ICSI outcomes. Over last 4 years, consenting men undergoing ART provided ejaculates for sperm chromatin fragmentation (SCF) screening before and after density gradient centrifugation (DGC). In a subsequent cycle, this assay was carried out microfluidics selection (MFSS). SCF assessed by terminal deoxynucleotid...