Neuroendocrine carcinomas of the esophagus are very rare, and the majority are high grade (poorly differentiated). They occur most frequently in males in their sixth and seventh decades of life. There have been no concrete data published on clinical features or on prognosis. We report a case of large-cell neuroendocrine carcinoma of the esophagus in a 66-year-old Saudi female with progressive d...

Neuroendocrine carcinoma and adenocarcinoma existing in the stomach simultaneously is extremely rare. This report presents a 65-year-old male patient who was diagnosed with three types of malignant tumors in the stomach, neuroendocrine carcinoma (NEC), moderately differentiated adenocarcinoma and mucinous adenocarcinoma. In addition, the NEC and moderately differentiated adenocarcinoma existed ...

Cancer of unknown primary site is a histologically confirmed cancer that manifests in advanced stage, with no identifiable primary site following standard diagnostic procedures. Patients are initially categorized based on the findings of the initial biopsy: adenocarcinoma, squamous-cell carcinoma, neuroendocrine carcinoma, and poorly differentiated carcinoma. Appropriate patient management requ...

Cancer of unknown primary site is a histologically confirmed cancer which is manifested in advanced stage, with no identifiable primary site after the use of standard diagnostic procedures. Patients are initially placed into one of categories based upon the examination of the initial biopsy: adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma and poorly differentiated carcinoma. A...

gastric neuroendocrine carcinoma is a rare tumor which has a poor prognosis. herein, we present a 55-year-old woman who presented with complaints of recurrent vomiting, hematemesis and weight loss. endoscopic examination showed a large ulcerated mass in the antrum. microscopic evaluation of the specimen taken through biopsy was compatible with a small round cell tumor. however, definitive histo...

primary neuroendocrine carcinoma (nec) of the mediastinum is a rare type of carcinoma. according to the literature, only five cases of this condition have been reported so far. in this paper, we present a rare case of mediastinal nec of unknown primary site. the patient was a 34-year-old man with mediastinal nec, who presented with chronic dry cough and a right-sided mediastinal mass one year p...