POEMS syndrome is a unique clinical entity, the diagnosis of which is made when polyneuropathy and monoclonal gammopathy occur together, associated with other changes such as organomegaly, endocrinopathy, skin changes and papilledema. Cutaneous manifestations are heterogeneous, with diffuse cutaneous hyperpigmentation, hemangiomas and hypertrichosis occurring more frequently. We report the case...

Cutaneous leishmaniasis is the most common form of leishmaniasis caused by flagellate protozoa of the genus Leishmania transmitted by sand fly bites. Old World leishmaniasis is endemic in the Mediterranean Sea and the neighbouring countries. We present a case of a 10-year-old boy with a cutaneous leishmaniasis in form of papules on the nose, right and left lower leg. Histopathological examinati...

The wide variety of Leishmania species responsible for human American cutaneous leishmaniasis combined with the immune mechanisms of the host results in a large spectrum of clinical, histopathological, and immunopathological manifestations. At the middle of this spectrum are the most frequent cases of localized cutaneous leishmaniasis (LCL) caused by members of the subgenera Leishmania and Vian...

The clinico-pathological and immunological findings in eight patients from Bahia, Brazil with disseminated cutaneous leishmaniasis are described. This condition differs from anergic diffuse cutaneous leishmaniasis (DCL) and from classical American cutaneous leishmaniasis (ACL). The number of lesions in these patients ranged from 75 to 800 and were characterized by papules and an acneiform type ...

Invasive meningococcal disease is a serious life-threatening infection. Skin rash is present in about half of the patients with meningococcal infection. However it could be easily missed if no thorough cutaneous examination is performed. Herein, we present a patient with invasive meningococcal serogroup B infection with diffuse cutaneous purplish rash and ecchymoses, suggestive of purpura fulmi...

Primary cutaneous B-cell lymphoma has only recently been recognized as a distinct clinical entity. Primary cutaneous diffuse large B-cell lymphoma of the legs generally occurs in elderly patients, in particular women. A 70-year-old female patient was admitted to our hospital with her nodular erythematous lesions localized on the left thigh. We performed an ultrasound and color Doppler ultrasoun...

We report a 54-year-old patient with the association of hepatic dysfunction with cyanosis, severe hypoxemia, platypnea-orthodeoxia, diffuse cutaneous spider nevi, telangiectasia, palmar erythema, digital clubbing and findings of marked intrapulmonary vascular dilation and arterovenous shunt. The diagnosis of hepato-pulmonary-cutaneous syndrome, a term we think more appropriate and inclusive tha...

MEN: multiple endocrine neoplasia PEN: palisaded and encapsulated neuroma PTEN: phosphatase and tensin homolog PTHS: PTEN tumor-hamartoma syndrome M ultiple cutaneous neuromas are an uncommon finding that has been reported to occur idiopathically and in association with multiple endocrine neoplasia (MEN) 2B and phosphatase and tensin homolog (PTEN) tumorhamartoma syndrome (PTHS). Multiple cutan...

Immunosuppressive drugs and biological agents may represent a potential risk of lymphoma development in patients with rheumatoid arthritis. But most cases are diffuse, large B-cell lymphomas. Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma, a provisional entity in the 2005 WHO-EORTC classification of cutaneous lymphomas, is only described in a limited number of reports. To...

Kindler syndrome (KS) is a rare, autosomal recessive genodermatosis characterized by skin blistering and photosensitivity in infancy, progressive poikiloderma, and diffuse cutaneous atrophy. It affects the skin, mucous membranes, and oral cavity and is caused by mutations in the KIND1 gene on 20p12.3. The first case of KS associated with periodontitis was reported in 1996, and have been infrequ...