Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL), which is the most common type of lymphoma. NHL comprises a group of clinically and biologically diverse diseases, which range from indolent to aggressive clinical courses. Despite treatment advances in the last three decades with the use of combination immunotherapy, a significant fraction...

editorial Diffuse large B-cell lymphoma of the breast: a distinct entity? The management of squamous cell carcinoma arising in the lung is markedly different than squamous cell carcinoma of the skin, cervix, or larynx. Likewise, the optimal management of diffuse large B-cell lymphoma sometimes varies by the primary site of involvement. Knowledge of the unique clinical behavior of lymphoma arisi...

Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy of mature B lymphocytes. It is known as a heterogeneous disease with variable therapeutic responses and alternative therapies. Morphological and immunophenotypical evaluation of the biopsy specimens can help diagnose DLBCL. Methods: In the current study, 44 patients were chosen from Shaheed Sadoghi Hospital (2010&nda...

Histone methylation and demethylation regulate B-cell development, and their deregulation correlates with tumor chemoresistance in diffuse large B-cell lymphoma, limiting cure rates. Since histone methylation status correlates with disease aggressiveness and relapse, we investigated the therapeutic potential of inhibiting histone 3 Lys27 demethylase KDM6B, in vitro, using the small molecule inh...

In the present study, we described cyto-histopathological features and immunophenotyping of the large B-cell lymphoma in an 8-year-old mixed breed dog with applying the World Health Organization (WHO) system of classification of canine lymphomas. In fine-needle aspiration (FNA), lymph nodes were involved by neoplastic cells of intermediate to large size with deep blue cytoplasm; consist of cent...

Lymphomas arising within the oral cavity account for only 3.5% of all oral malignancies. Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma subtype characterized by diffuse proliferation of large neoplastic B lymphoid cells. This paper reports a case of diffuse large B-cell lymphoma affecting the oral cavity of a Brazilian woman, along with its clinical, microscopical, immunohistochemical,...

primary adrenal lymphoma is extremely rare. we report a case with primary bilateral adrenal lym-phoma in a young male patient. he presented with abdominal pain and weight loss. pathologic study revealed malignant lymphoma, diffuse large cell type (t- cell origin). patient recieved combination chemotherapy and radiation therapy but 22 months after diagnosis died because of progression of dis ease

the patient was a 67-year-old female who presented with severe rectal bleeding since three days prior to hospital admission. she complained of mild abdominal pain. rectal examination revealed the presence of fresh blood and a clot. she had a normal upper endoscopy. a colonoscopy showed a large clot with bloody secretions up to the cecum, with no obvious origin. because of the severity of bleedi...

Primary testicular lymphoma (PTL) is a rare form of extranodal lymphoma, this neoplasm the most common malignant tumor testis in elderly age, and majority cases are histologically diffuse large B-cell (DLBCL), accounting for 80% to 98% non-hodgkin lymphoma. Patients with primary DLBCL show continuously high risk recurrence no plateau survival curves tendency involve other sites, especially cent...