Bioactive dihydropyrimidinones (DHPs) were designed and synthesized by a multicomponent Biginelli reaction. The reaction was catalyzed the polarized surface of nano-zirconium dioxide with partial positive charge 0.52e at Zr center negative ?0.23e oxygen center. There good corroboration between computed experimental ZrO2 cell parameters bond distances as determined in silico vitro methods. Since...

alkali and alkaline earth metals hydrogen sulfate catalyzed the one-pot three component condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under solvent-free conditions leading to 3,4-dihydropyrimidin-2(1h)-ones in high yields at 80 °c. our results showed that biginelli reaction not only is ph dependent, but the cation of catalyst plays an important role.

A green methodology for the development of the synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction by using cyclohexane-1,4-diyl bis (hydrogen sulfate) (CDBH) as an effective catalyst in water and solvent-free conditions was reported. This sulfonated catalyst is an efficient and environmentally benign homogeneous catalysts which characterized by using different tech...

3,4-Dihydropyrimidinones and their derivatives are synthesized via Biginelli routes involving an aromatic aldehydes, ethylacetoacetates and urea in one-pot procedure by using CdS nanoparticles as efficient heterogeneous catalyst in solvent-free conditions. Compared with classical Biginelli reaction reported in 1893, this new method provides much improved modification in terms of simplicity. The...

Multicomponent reactions are excellent methods that meet the requirements of green chemistry, by reducing the number of steps, and consequently reducing purification requirements. Accordingly, in this work, 11 novel hybrid-boron-containing molecules, namely eight 1,4-dihydropyridines and three 3,4-dihydropyrimidinones, derived from formylphenylboronic acids (ortho, meta and para), were obtaine...

Dietary long-chain fatty acid (LCFA) uptake across cell membranes is mediated principally by fatty acid transport proteins (FATPs). Six subtypes of this transporter are differentially expressed throughout the human and rodent body. To facilitate drugs discovery against FATP subtypes, the authors used mammalian cell lines stably expressing the recombinant human FATP4 and 5 and developed a high-t...