The FHIT gene plays important roles in cancer development, including lung cancers, in which the Fhit protein is frequently lost. To determine if Fhit-deficient mice exhibit increased susceptibility to carcinogen-induced lung cancer, mice were treated with the pulmonary carcinogen 4-methylnitrosamino-1-3-pyridyl-1-butanone. Wild-type and Fhit-deficient animals did not exhibit significantly diffe...

1. Rats were given the hepatotoxin and carcinogen cycasin by stomach tube. In one experiment, rats whose RNA had previously been labelled with [(14)C]-formate were given the acetate ester of the aglycone form of cycasin, methylazoxymethanol, by intraperitoneal injection. 2. Incorporation of (14)C from l-[U-(14)C]leucine into the proteins of some organs was measured in cycasin-treated rats. Cyca...

The hepatotoxic effects of the oral administration of a single dose of 50 mg dimethylnitrosamine (DMN)/kg and daily doses of 5 mg and 1 mg/kg, respectively, to cats and lizards were studied by light microscopy. Centrilobular necrosis was the main alteration detected in the liver of cats as in other animal species studied. The lizards, however, appeared unaffected. Morphological changes observed...

N-nitrosodimethylamine (NDMA) is a potential carcinogen frequently found in treated wastewater as a byproduct of chlorination. The potential for NDMA to contaminate the groundwater is a significant concern. A solute fate and transport model, Hydrus-1D, was used to evaluate the leaching potential of NDMA under different irrigation practices and soil properties. The results indicate that the risk...

Given a family X(t) of continuous–time nearest–neighbor random walks on the one dimensional lattice Z, parameterized by n ∈ N+, we show that the spectral analysis of the Markov generator of X with Dirichlet conditions outside (0, n) reduces to the analysis of the eigenvalues and eigenfunctions of a suitable generalized second order differential operator −DmnDx with Dirichlet conditions outside ...

To know the conditions of contamination by the chemicals in the experimental animal diets, the contents of nitrosodimethylamine (NDMA) were analyzed in the diets for mice and rats. The raw materials of the diets were also analyzed. In addition, NDMA levels were determined in the diets which were stored long or heated in the autoclaves. The averages of NDMA in these diets were less than 10 ppb. ...