نتایج جستجو برای: dio2 gene
تعداد نتایج: 1141419 فیلتر نتایج به سال:
Introduction: Depressive disorders are multifactorial diseases in that a variety of factors may play role their etiology, including inflammation and abnormalities the thyroid hormone (TH) metabolism levels. The purpose this study was to evaluate iodothyronine deiodinases (DIOs) DIO-interacting cytokines as possible biomarkers diagnosis depressive disorders. Methods: This enrolled 73 patients di...
In mammals, day-length-sensitive (photoperiodic) seasonal breeding cycles depend on the pineal hormone melatonin, which modulates secretion of reproductive hormones by the anterior pituitary gland [1]. It is thought that melatonin acts in the hypothalamus to control reproduction through the release of neurosecretory signals into the pituitary portal blood supply, where they act on pituitary end...
In nature Siberian hamsters utilize the decrement in day length following the summer solstice to implement physiological adaptations in anticipation of the forthcoming winter, but also exploit an intrinsic interval timer to initiate physiological recrudescence following the winter solstice. However, information is lacking on the temporal dynamics in natural photoperiod of photoperiodically regu...
Animals living in temperate zones anticipate seasonal environmental changes to adapt their biological functions, especially reproduction and metabolism. Two main physiological mechanisms have evolved for this adaptation: intrinsic long-term timing mechanisms with an oscillating period of approximately 1 year, driven by a circannual clock [1], and synchronization of biological rhythms to the sid...
Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) that selectively antagonizes the FGFR1c isoform, we investigated possible actions of FGFR1c in a natural animal model of adiposity, the Siberian hamster....
Abstract Background The oviduct of a hen provides conducive environment for egg formation, which needs large amount mineral elements from the blood via trans-epithelial permeability. Eggshell is calcified layer on outside an that protection and critical quality. However, little known about genes or proteins involved in eggshell their relationship to dietary microminerals. We hypothesized seleni...
Thyroid hormone action is an important determinant of energy and glucose metabolism. T4 metabolism is regulated by the deiodinases of which type 2 is expressed in humans in skeletal muscle and brown adipose tissue, where its transcription is stimulated by the -3 adrenergic pathway. We performed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a novel variant for assoc...
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