Three metabolites appearing in the urine of animals after the ingestion of the flavonol quercetin (1, 2) having been identified, our interests were next centered on similar studies of several citrus flavonoids. Here again our primary concern was to find evidence, if any, that these compounds are absorbed from the gastrointestinal tract after oral ingestion and, secondly, if absorption does take...

The aim. To conduct a comprehensive study of biphasic-type suppositories that contain diosmin and hesperidin.
 Materials methods. Samples with mass 4.0 were objects the study. Pharmacological, technological analytical research methods used to directly or indirectly analyze strength completeness drug activity. Thus, in this work we combined specificity pharmacological action drug, experimen...

Three metabolites appearing in the urine of animals after the ingestion of the flavonol quercetin (1, 2) having been identified, our interests were next centered on similar studies of several citrus flavonoids. Here again our primary concern was to find evidence, if any, that these compounds are absorbed from the gastrointestinal tract after oral ingestion and, secondly, if absorption does take...

In this study, the effectiveness of vasoprotective Diosmin for prevention pre-eclampsia in pregnant women high-risk group with severe forms placental insufficiency was evaluated. The choice prophylactic agent clinical is justified by close pathogenetic relationship between and on one hand, proved fetoprotective action case other hand. It shown that a normalizing effect uterine-placental- fetal ...

The pharmacological effects on the central nervous system (CNS) of a range of available flavonoid glycosides were explored and compared to those of the glycosides 2S-hesperidin and linarin, recently isolated from valeriana. The glycosides 2S-neohesperidin, 2S-naringin, diosmin, gossipyn and rutin exerted a depressant action on the CNS of mice following i.p. injection, similar to that found with...

The cyclin-dependent kinase 4 (CDK4)-cyclin D1 complex plays a crucial role in the transition from the G1 phase to S phase of the cell cycle. Among the CDKs, CDK4 is one of the genes most frequently affected by somatic genetic variations that are associated with various forms of cancer. Thus, because the abnormal function of the CDK4-cyclin D1 protein complex might play a vital role in causing ...

Background: Heavy menstrual bleeding (HMB) is defined as cyclical at regular intervals but excessive in amount which affect the physical, social and mental aspects of life a woman. The prevalence 10-30% reproductive age women 50% perimenopausal women. HMB not just clinical burden also huge economic burden. aims objective my study to compare efficacy diosmin tranexamic acid acute terms average d...