Introduction: Medications used to treat oral ulcers include corticosteroids, anesthetics, and antihistamines. These can be as gels, mouthwashes, pastes, ointments, etc. Diphenhydramine hydrochloride (DPH) has local anesthetic properties that help the aphthae. One of drawbacks delivery transmucosal is quick turnaround time gel, a mucous form located on epithelial film surface. Methods: Therefore...

Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. The chemical structure of cloperastine is quite similar to that of the antihistamine drug diphenhydramine, which is reported to inhibit hERG K⁺ channels and clinically induce long QT syndrome after overdose. To analyze its proarrhythmic potential, we compared effects of cloperastine and diphenhydram...

BACKGROUND We present the first full case report of the treatment of mast cell activation syndrome with continuous diphenhydramine infusion, which resulted in the improvement of anaphylactic reactions and a decrease in hospital readmission. Furthermore, the patient received imatinib in the absence of the KIT-D816V mutation, which led to further improvement of quality of life. Currently, we are ...

Abstract Background The urine immunochromatographic assay is a useful screening tool for patients suspected of acute drug intoxication in emergency conditions. Diphenhydramine shows symptoms similar to those tricyclic antidepressant (TCA) intoxication. Case presentation We examined case diphenhydramine showing cerebellar ataxia and prolonged false positive results TCA the urine. test showed per...

Diphenhydramine, as an antihistamine drug is widely used for the treatment of allergies. However, being classified as an over the counter medication and the general belief on the low adverse effect profile of this drug has made it widely accessible to the families. Recent reports of diphenhydramine intoxication and mortality, noticeably in children and infants have raised some serious concerns....

OBJECTIVE The authors sought to identify patterns and associations of prescription and over-the-counter sedative-hypnotic use in an older, rural, blue-collar, community-based cohort in southwestern Pennsylvania over 10 years. METHODS A group of 1,627 individuals age 65 and over were recruited and assessed during 1987-1989 and re-assessed during approximately biennial waves. Data included slee...

The aim of this work is to develop and validate simple, sensitive, selective and cost effective spectrophotometric methods for the determination of tetramisole hydrochloride in the presence of its alkali-induced degradation product without preliminary separation. These methods namely ratio difference [11,12], derivative ratio [13,14], mean centering [15,16] and continuous wavelet transform [17,...

Thiopropazate (Dartalan) was found to be significantly more effective than a placebo in relieving dyskinesia in 23 patients with functional psychosis and persistent dyskinesia associated with prolonged phenothiazine therapy. Each patient whose dyskinesia had persisted unchanged for at least one month after phenothiazine withdrawal received thiopropazate by mouth for three weeks and the placebo ...