Vitamins are widely used as a prescription medicine. The aim of the study is to prepare pyridoxine HCl tablets (200 mg) using direct compression technique which is now a days considered a cost effective and simple method of formulation. It can be considered as an appropriate method for hygroscopic and thermolabile substances. In the present study new formulations of Pyridoxine HCl was manufactu...

Color lookup tables (CLUTs) that are embedded in printer firmware consume precious flash memory. In order to conserve memory and thereby reduce cost, it is desirable to compress CLUTs prior to storage and restore tables as required. In this paper, we investigate methods for lossless compression of CLUTs. We demonstrate that, through suitable pre-processing of data, significant improvements in c...

In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol 400 and glycerin). The ratio of microcrystalline cellulose (as carrier) to silica (as coating powder material) was 20 for all formulations. Afte...

The topic of this article is the compression physics of different gum bases which can be used to prepare chewing gumtablets by direct compression. Three different gum bases, Pharmagum® C, M and S, were tested alone and in differentcombinations. The preparations were compressed with a Korsch EK0 eccentric tableting machine at compressionforces of 5, 7.5, 10, 12.5 and 15 kN. The c...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...

Real time changes of the GaAs band structure were determined using time-resolved photoluminescence PL spectroscopy, with nanosecond resolution, in single-event continuous compression experiments. Continuous compression to 5 GPa over 150 ns was achieved by impacting fused silica buffers preceding the GaAs crystals. PL spectra and compression wave profiles were measured simultaneously for uniaxia...

The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (HPMC) as release retardants. The suitability of light grade cashew gum as a direct compression excipient was studied using the SeDeM Diagram Expert System...

The mechanism of forward flow produced by precordial compression during CPR was investigated with the aid of echocardiographic and hemodynamic measurements in anesthetized, mechanically ventilated domestic pigs. Both mitral and tricuspid valves opened during compression diastole and closed during compression systole. Valve motion persisted throughout resuscitation in 17 of 22 animals which were...

The direct compression suitability of active pharmaceutical ingredients could be studied by SeDeM diagram method. Cefuroxime axetil (CfA) and paracetamol (PCM) were employed for SeDeM studies as these powders are well-characterized and known to be particularly difficult with respect to flowability and compactibility. Twelve different selected pharmacotechnical parameters were determined experim...