Upon HIV infection diagnosis, an 8-month-old boy was transferred for evaluation of worsening respiratory distress requiring mechanical ventilation. Pneumocystis jirovecii pneumonia (PCP) was diagnosed; the boy also had a nonhealing ulcer at the site of vaccination with Statens Serum Institut (Danish strain) Bacillus Calmette-Guérin (BCG) vaccine and associated axillary lymphadenopathy. PCP trea...

BACKGROUND Bacille Calmette-Guérin (BCG)--a live, attenuated vaccine--is routinely given to neonates in settings where tuberculosis is endemic, irrespective of human immunodeficiency virus (HIV) exposure. HIV-infected infants and other immunodeficient infants are at risk of BCG-related complications. We report the presentation, treatment, and mortality of children who develop BCG disease, with ...

Introduction / objectives The attenuated bacilli Calmette-Guerin (BCG) vaccine is administered in Albania to all newborns at the first day of life to prevent tuberculosis. Although complications are rare after BCG vaccination and the outcome is usually favourable, serious BCG infections can occur. The risks associated with BCG vaccination include local complications, extraregional localized dis...

An 8-year-old girl died of sepsis due to staphylococcal infection one year and 8 months after Bacille Calmette-Guerin (BCG) revaccination. Two months after the vaccination in accordance with the school health program, she was hospitalized with a high fever, skin rash over the face and lower limbs, and leukopenia. Her clinical and laboratory pictures were not compatible with those of any establi...

we have reviewed the medical records of 40 patients with disseminated (bacille calmette-guerin) bcg from 1996 to 1999 in the immunology department of the children hospital, medical center, tehran university. these patients are divided in to 3 groups: 1. patients who had disseminated (bacille calmette-guerin) bcg after vaccination and their diagnosis was chronic granulomatous disease. 2. patient...

disseminated tuberculosis (tb) is commonly seen in hiv-infected patients and is major cause of death in these patients. in hiv-infected patients disseminated tuberculosis is frequently undiagnosed or misdiagnosed. in this article we report a case of disseminated tb in a hiv-infected patient with a relatively long history of fever and other complaints without definite diagnosis. diagnosis of dis...

conclusions combination therapy with surgical excision has a synergistic effect and appears to be the best treatment for extended lesions. however, new potent antibacterial drugs may help to improve the management of such infections when there are sufficient data on their in vitro activity. introduction nocardia species are described as opportunistic pathogens that mainly cause pulmonary nocard...

The pathologic findings from biopsy specimens from 9 patients with postvaccination bacille CalmetteGuérin (BCG) infection are presented. The patients were vaccinated with BCG during the first 2 days of life. Four patients had normal immunity and 5 patients were immunocompromised. The pathologic findings in both groups were different. Biopsy specimens from patients with normal immunity showed mu...

Mycobacterium bovis BCG is one of the most commonly administered vaccines. Complications, including disseminated BCG disease, are rare but increasingly reported in immunodeficient children. There is growing recognition of the importance of differences between BCG vaccine strains. We determined the susceptibilities of five genetically distinct BCG vaccine strains to 12 antituberculous drugs.

the only available vaccine against tuberculosis is bcg which has been found to protect children against disseminated tuberculosis and tuberculous meningitis. bcg is one of the safest vaccines being used, and osteitis is a rare complication of it. during a period of eight years, we had eleven cases of osteitis occuring in infants following bcg vaccination. eight cases were female. defect in immu...