Isradipine belong to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is used in the treatment hypertension, angina pectoris, addition Parkinson disease. goes under BCS II drug (low solubility-high permeability). The will experience extensive first-pass metabolism liver, therefore, oral bio-availability be approximately15 24 %.
 
 aim this study was formulate and opt...