A new loop diuretic with uricosuric activity, 6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydro-2-benzofuran carboxylic acid (S-8666), was given orally at 12:00 a.m. or 12:00 p.m. in rats. The diuretic of S-8666 and the urinary excretions of the drug and its active metabolite S-8680 (N-demethyl S-8666) were greater at 12:00 a.m. than at 12:00 p.m. Thus, the present study indicates that the diu...

By selectively regulating solute or fluid reabsorption, the kidneys play the major role in maintaining the volume and composition of extracellular fluid. Many diseases, including congestive heart failure, hepatic cirrhosis, and Cushing’s syndrome (glucocorticoid excess), are associated with or cause significant alterations in extracellular fluid balance. Diuretics inhibit renal sodium transport...

Several species of the genus Piper are known in Brazilian folk medicine as having diuretic activity. So, we propose to investigate the acute diuretic activity and the possible toxic effects of Piper glabratum Kunth, popularly known as false Jaborandi. Additionally, we propose to check whether there is any correlation between the biological activities of the crude extract (MEPG) and its 2-methox...

Alocasia macrorrhizos (AM) belongs to the family Araceae, different parts of this plant have shown hepatoprotective, anti-oxidant and anti-inflammatory action. Though it is traditionally used as a diuretic it needs substantial experimental evidence to support this. Hence we aimed to evaluate the diuretic activity of hydroalcoholic extract of leaves of AM in wistar rats. Acute diuretic activity ...

introduction: urinary obstructive disease is one of the most common disorders in urinary system. dilatation which is detected by sonography, is a key finding in obstruction in most of the cases, also could be found following surgery, lithotripsy and vesico–urethral reflux. radioistope diuretic washout renography is a useful method to differentiate mechanical and non mechanical obstruction. mate...

In 4 patients with cirrhosis and ascites, diuretic therapy resulted in an impairment of renal function that was associated with a rise in plasma renin activity (PRA). In 3, this occurred in the absence of volume depletion. When diuretics were discontinued, renal function returned to normal. beta-adrenergic blocking drugs were then given to suppress renin secretion and diuretics restarted. On th...

The diuretic response to loop diuretics in various disease states has consistently been found to be subnormal. One of the key determinants of the degree of diuretic response is the functional integrity of the sodium-potassium-chloride transporter in the loop of Henle. Studies in animal models suggest that expression/activity of the transporter may be affected by factors such as altered natural ...

The benzene, alcoholic and aqueous root extracts (75mg/kg each)of Dalbergia spinosa Roxb were studied for its diuretic activity by using male albino rats by adopting the method of Tipschitz. The alcoholic extract increased the urine volume and electrolytes sodium, potassium and chloride, which is similar to the standard drug Furosemide (100mg/ kg) by inhibiting sodium, potassium, and chloride i...