The tolerance and bioremoval of dimethylarsinic acid (DMA(V)) by Acidithiobacillus ferrooxidans (A. ferrooxidans) were investigated here. The inhibitory concentration (IC) of DMA(V) was determined for A. ferrooxidans. The effects of various parameters such as pH, contact time, initial DMA(V) concentration, biosorbent dose and temperature were systematically examined to study the biosorption pro...

Arsenic is a well-documented human carcinogen, and contamination with this heavy metal is of global concern, presenting a major issue in environmental health. However, the mechanism by which arsenic induces cancer is unknown, in large part due to the lack of an appropriate animal model. In the present set of experiments, we focused on dimethylarsinic acid (DMA), a major metabolite of arsenic in...

AIMS To study the concentration of N,N-dimethylacetamide (DMA) and its metabolite, N-methylacetamide (NMA), in urine of workers occupationally exposed to DMA in a factory producing synthetic acrylic fibres. METHODS During the first phase, 223 workers exposed to low environmental concentrations of DMA provided urine samples at the end of a work shift. High concentrations of the unmodified solv...

The disordered-molecular-alloy phase (DMA) of ammonia hydrates [J. S. Loveday and R. J. Nelmes, Phys. Rev. Lett. 83, 4329 (1999)] is unique in that it has substitutional disorder of ammonia and water over the molecular sites of a body centred cubic lattice. Whilst this structure has been observed in ammonia di- and mono-hydrate compositions, it has not been conclusively observed in the ammonia ...

The effect of dimethyl adipimidate (DMA), an amino-reactive crosslinking reagent with demonstrated antisickling properties in vitro, on the survival of 51Cr-labeled autologous sickle cells was evaluated in five adult males with sickle cell anemia. The survival of cells pretreated with 5 mmol/L DMA (pH 7.4), normal (t1/2 28-33 days) in four subjects and near-normal (t1/2 20 days) in the fifth, w...

Being low molecular weight carbon (LMW-C) compounds, phytosiderophores (PS) released by strategy II plants are highly susceptible to microbial decomposition. However, to date very little is known about the fate of PS in soil. Using in-house synthesized C4-20-deoxymugineic acid (DMA), the main PS released by wheat, we investigated DMA mineralization dynamics, including microbial incorporation in...

Dimethylarsinic acid (DMA(V)) is carcinogenic to the rat urinary bladder, but not in mice. The carcinogenic mode of action involves cytotoxicity followed by regenerative cell proliferation. Dietary DMA(V) does not produce urinary solids or significant alterations in urinary composition. The cytotoxicity is due to formation of a reactive metabolite, likely dimethylarsinous acid (DMA(III)), conce...

Radiotherapy, a therapeutic modality of cancer treatment, nonselectively damages normal tissues as well as tumor tissues. The search is ongoing for therapeutic agents that selectively reduce radiation-induced normal tissue injury without reducing tumoricidal effect, thereby increasing the therapeutic ratioof radiation therapy. Our laboratory established 5-(4-methylpiperazin-1-yl)2-[2ʹ-(3,4-dime...

Changes in total volatile bases (TVB), dimethylamine (DMA), formaldehyde (FA), trimethylamine (TMA) and trimethylamine oxide (TMAO) of whole hake (Merluccius merluccius L.) were evaluated at different temperatures of storage: -5, -12 and -20°C. Significant changes in TVB, DMA, TMA, TMAO nitrogen and FA were observed at 5°C. Only TMAO changed significantly at -12°C and -20°C. TMAO decrease was n...