myostatin gene or growth and differentiation factor-8 inhibits the puberty and development of skeletal muscles and it could change the size of some muscles such as double muscle, if the mutation occurs. one of the most important indigenous sheep in iran, lori sheep, possess high genetic potential for meat production. therefore, the study of some genes affecting meat production would be of utmos...

Abstract Background Breast cancer, one of the most prevalent cancer types among women worldwide as well in Bangladesh, is leading cause death throughout globe. The risk breast development was found to be associated with genetic polymorphism according several studies. As a convenient prognostic marker, biomarker helps identify disease progression, can lead an effective therapeutic strategy, mark...

conclusions imp3 immunoreactivity was associated with poor differentiation of tumor yet not associated with tumor size depth of invasion or lymph node involvement. results immunoreactivity pattern of imp3 was cytoplasmic in different clinicopathologic findings. among different clinicopathologic findings, we found a statistical relationship between tumor differentiation and imp3 (p = 0.047); so ...

the objective of the present study was to detect polymorphism in follicle stimulating hormone receptor (fshr) and beta subunit of follicle stimulating hormone (fshβ) genes and their relation to litter size and body weight trait in baluchi, iran black and arman sheep breeds. pcr-rflp technique using acci and hinfi enzyme treatments employed to detection of polymorphism in fshβ marker site but de...

the availability of the saturated dna marker maps in livestock has made it possible to locate quantitative trait loci (qtl) in these domestic animals. the objective of this research was to investigate the principles of applying the simple regression for qtl analysis in paternal half-sib (phs) design commonly used in livestock species. the theoretical aspects of the simple regression approach fo...

We describe a dominant behavioral marker, rol-6(su-1006), and an efficient microinjection procedure which facilitate the recovery of Caenorhabditis elegans transformants. We use these tools to study the mechanism of C.elegans DNA transformation. By injecting mixtures of genetically marked DNA molecules, we show that large extrachromosomal arrays assemble directly from the injected molecules and...

linked and/or gene-based molecular markers have been used widely in marker-assisted selection (mas) to differentiate resistant and susceptible genotypes. resistance to meloidogyne spp. in beta vulgaris l. is mediated by a single dominant gene (r6m-1). using allele-specific primers (asps), an snp marker harboring a single nucleotide polymorphism (a/g), linked to the resistance gene was developed...

Figure 1. Detection of Borna disease virus (BDV)–specific nucleic acid in peripheral blood mononuclear cells (PBMC) of a man with chronic fatigue syndrome (CFS), by nested and seminested polymerase chain reaction assays. Lanes: A, BDV-negative PBMC; B, BDV-specific amplicates from PBMC of patient with CFS; M, size marker (100-bp DNA ladder). Demonstration of Borna Disease Virus Nucleic Acid in ...

We have developed a system that utilizes human DNA-derived yeast artificial chromosomes (YACs) as marker chromosomes to study factors that contribute to the fidelity of meiotic chromosome transmission. Since aneuploidy for the YACs does not affect spore viability, different classes of meiotic missegregation can be scored accurately in four-viable-spore tetrads including precocious sister separa...

Previous studies describe a correlation between HPV-positivity and non-smoking in TSCC; p16INK4A-expression as surrogate-marker for HPV-DNA/RNA-positivity is discussed controversial. Here, these parameters are assessed prospective, consecutive setting. HPV-status of sputum tonsillar swabs analyzed to determine their validity tissue-HPV-status.