Melanocortinergic and dopaminergic systems are widely distributed in the CNS and have been established as a crucial regulatory component in diverse physiological functions. The pharmacology of both melanocortinergic and dopaminergic systems including their individual receptors, signaling mechanisms, agonists and antagonists has been extensively studied. Several lines of evidence showed that the...

To delineate the modulatory effects of induced positive affect on cognitive control, the current study investigated whether positive affect increases the ability to suppress a reflexive saccade in the antisaccade task. Results of the antisaccade task showed that participants made fewer erroneous prosaccades in the condition in which a positive mood was induced compared to the neutral condition ...

Spectrophotometric and electrochemical studies were successfully used in quantitative analysis of Amitriptyline Hydrochloride (ATH) and Nortriptyline Hydrochloride (NTH). Conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. Two new methods using spectrophotometry are dascribed for the determination of (ATH) and (NTH) with potassium b...

buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. a mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.in this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

The results of a series of ab initio (3-21G) and semiempirical (PM3) molecular orbital (MO) calculations on neutral, zwitterionic and cationic forms of dopamine [1,2-benzenediol-4(2-aminoethyl)] are reported. In particular, optimised geometries, relative stabilities, dipole moments and electron charge distributions for the relevant conformational states of the studied molecules are presented an...

OBJECTIVE To study the frequency and severity of acute orthostatic hypotension (OH) in patients with Parkinson's disease who are starting dopamine agonist therapy. PATIENTS AND METHODS In the context of an outpatient clinical practice, 29 consecutive patients with Parkinson's disease who were starting dopamine agonist therapy were brought into the clinic for their first dose of agonist. After...

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The implementation of computer games in physical therapy is motivated by characteristics such as attractiveness, motivation, and engagement, but these do not guarantee the intended therapeutic effect of the interventions. Yet, these characteristics are important variables in physical therapy interventions because they involve reward-related dopaminergic systems in the brain that are known to fa...