Large-size 0.1 Yb2O3–1.0 Al2O3–98.9 SiO2 (mol%) core glass was prepared by the sol–gel method. Its optical properties were evaluated. Both large mode area double cladding fiber (LMA DCF) with core diameter of 48 μm and large mode area photonic crystal fiber (LMA PCF) with core diameter of 90 μm were prepared from this core glass. Transmission loss at 1200 nm is 0.41 dB/m. Refractive index fluct...

The timing of cyclophosphamide (CY) administration after tumor inoculation was found to be critical for successful ther apy of MOPC-315 tumor-bearing mice. Following inoculation with 3.5 x 106 viable tumor cells, a single i.p. injection of CY (15 mg/kg) into mice bearing 10to 25-mm (Days 8 to 14) tumors cured most mice, whereas injection into mice bearing nonpalpable (Day 4) tumors cured only a...

The timing of cyclophosphamide (CY) administration after tumor inoculation was found to be critical for successful ther apy of MOPC-315 tumor-bearing mice. Following inoculation with 3.5 x 106 viable tumor cells, a single i.p. injection of CY (15 mg/kg) into mice bearing 10to 25-mm (Days 8 to 14) tumors cured most mice, whereas injection into mice bearing nonpalpable (Day 4) tumors cured only a...

The zebrafish embryo is now commonly used for basic and biomedical research to investigate the genetic control of developmental processes and to model congenital abnormalities. During the first day of life, the zebrafish embryo progresses through many developmental stages including fertilization, cleavage, gastrulation, segmentation, and the organogenesis of structures such as the kidney, heart...

We study by molecular dynamics computer simulation a binary soft-sphere mixture that shows a pronounced difference in the species' long-time dynamics. Anomalous, power-law-like diffusion of small particles arises that can be understood as a precursor of a double-transition scenario, combining a glass transition and a separate small-particle localization transition. Switching off small-particle ...

Cryogenic fluorescent light microscopy of flash-frozen cells stands out by artifact-free fixation and very little photobleaching of the fluorophores used. To attain the highest level of resolution, aberration-free immersion objectives with accurately matched immersion media are required, but both do not exist for imaging below the glass-transition temperature of water. Here, we resolve this cha...