نتایج جستجو برای: dqb1
تعداد نتایج: 1323 فیلتر نتایج به سال:
The critical role of the human leukocyte antigen (HLA) system in presenting peptides to antigen-specific T cell receptors may explain why only some human papillomavirus (HPV)-infected women progress to cervical cancer. HLA class II DRB1 and DQB1 genes were examined in 315 women with invasive squamous cell cervical cancer (SCC) and 381 control subjects. Increased risks of SCC were associated wit...
Objective To better characterize the genetic association between human leukocyte antigen (HLA) and anti-IgLON5 disease to explore auto-antigen binding associated HLA molecules their functional involvement in pathophysiology. Background Anti-IgLON5 is a rare, but likely underdiagnosed type of autoantibody encephalitis with heterogeneous clinical phenotype, including sleep, movement brainstem dys...
BACKGROUND Kazakhstan has been inhabited by different populations, such as the Kazakh, Kyrgyz, Uzbek and others. Here we investigate allelic and haplotypic polymorphisms of human leukocyte antigen (HLA) genes at DRB1, DQA1 and DQB1 loci in the Kazakh ethnic group, and their genetic relationship between world populations. METHODOLOGY/PRINCIPAL FINDINGS A total of 157 unrelated Kazakh ethnic in...
OBJECTIVE In the oligoarticular subgroup of juvenile idiopathic arthritis, a strong association has been found with the expression of human leukocyte antigen class II molecules HLA-DQA1 *0401-DQB1*0402 and DQA1*0501-DQB1*0301, whereas DQA1*0501-DQB1*0201 is neutral and DQA1 *0201-DQB1*0201 protective. A presentation of different peptides by these DQ alleles would support their role in the disea...
BACKGROUND Patients with type 1 diabetes mellitus (T1DM) have an increased risk of celiac disease (CD). Both diseases have a common genetic susceptibility locus in the human leukocyte antigen (HLA) class II alleles. Testing for tissue transglutaminase antibodies (anti-tTG) is highly accurate for a CD diagnosis. OBJECTIVE To determine the frequency of HLA-DQB1*0201/02 and DQB1*0302 alleles and...
STUDY OBJECTIVES To identify rare allelic variants and HLA alleles in narcolepsy patients with hypocretin (orexin, HCRT) deficiency but lacking DQB1*06:02. SETTINGS China (Peking University People's Hospital), Czech Republic (Charles University), Denmark (Golstrup Hospital), Italy (University of Bologna), Korea (Catholic University), and USA (Stanford University). DESIGN CSF hypocretin-1, D...
Asthma is a complex and multifactorial disorder. Several studies have reported association between different HLA- DQB1 and HLA- DRB1 alleles and allergic asthma. The aim of the present study was to investigate the association of HLA-class II alleles and haplotypes, with total serum IgE and the results of the skin prick test in Iranian children with allergic asthma. A total of 112 patients with ...
asthma is a complex and multifactorial disorder. several studies have reported association between different hla- dqb1 and hla- drb1 alleles and allergic asthma. the aim of the present study was to investigate the association of hla-class ii alleles and haplotypes, with total serum ige and the results of the skin prick test in iranian children with allergic asthma. a total of 112 patients with ...
هدف: تأثیر آلل ها، ژنوتیپ ها و هاپلوتایپ های hla–drb1 و hla–dqb1 بر سن شروع بیماری دیابت نوع یک در ایران بررسی شد. مواد و روش ها: آلل های hla–drb1, -dqb1 در 105 بیمار دیابتی نوع یک و 100 فرد سالم از قومیتهای مختلف، با سن شروع بیماری مقایسه شد. بیماران براساس سن شروع بیماری به 4 گروه سنی (1-5، 6- 10، 11-15، 16- 20 سالگی) طبقه بندی شدند و فراوانی هر یک از آلل ها، ژنوتیپ ها و هاپلوتایپ های مستعد...
INTRODUCTION Rheumatoid arthritis is an autoimmune disease with poorly understood pathophysiology. Genetic components of disease etiology, especially human leukocyte antigen (HLA) associations, are well known. Ethnic differences account for a number of variations in disease association with the HLA locus and there seem to be differences in various studies regarding its genetic predisposition. T...
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