Poly(D,L-lactide-co-glycolide) and poly(D,L-lactide-co-glycolide) with poly(ethylene glycol) nanospheres (NSs) incorporating flurbiprofen (FB) were freeze-dried with several cryoprotective agents and sterilized by γ-irradiation. Only when 5.0% (w/v) hydroxypropyl-β-cyclodextrin (HPβCD) was used, a complete resuspension by manual shaking and almost identical particle size of the NSs was obtained...

Background. Rabbit skin model was used to test skin irritation of the most commonly used cosmetic products in Jimma town, southwestern Ethiopia. The most commonly used cosmetics were Dove, Glysolid, College, Top Society, Fair and Lovely, Nivea, Lux, Magic fruit world, Solea, Body talk, Kris, Holly, Victoria, and Sweet Heart. Methods. Intact and abraded rabbit skins were tested for erythema and ...

PURPOSE Ocular side effects in patients using eye drops may be due to intolerance to the vector used in eye drops. Castor oil is the commonly used lipophilic vector but has been shown to be cytotoxic. Effects on cells of four oils (olive, camelina, Aleurites moluccana, maize) were compared with those of castor oil in human conjunctival cells. METHODS Human conjunctival cells were incubated wi...

Aim: This study was conceived for the purpose of evaluating dermal toxicity potentials of extracts from S. glaucescens which is known for many traditional application in human and animals including healing wounds, boils, HIV, worms and application on the swollen lymph nodes of cattle suffering from east coast fever (ECF). This followed the scanty availability of information regarding Original R...

Sulphur mustard (SM), chemically bis (2-chloroethyl) sulphide is a bifunctional alkylating agent that causes cutaneous blisters in human or animals. There is no specific therapy for SM induced skin injury, however, DRDE/WH-02 (containing PVP-I, Aloe vera gel and betaine) has proved to be an effective remedy for SM dermatotoxicity in preclinical studies. This study was planned to evaluate safety...

Background: In the mammalian system, hair follicle is known to be most significant organ that determines appearance, gender distinction, provides intense temperature protection, and plays a role in self-defense. The younger generations have begun suffer from extreme loss problems due many lifestyle-related changes such as fatigue, anxiety, intake of junk foods, use different hairstyling/colorin...