Toxicokinetic investigations are an essential component of nonclinical toxicology studies and generally rely on bioanalysis of plasma samples, which requires relatively large volumes of blood and, often, additional numbers of animals. Dried blood spot (DBS) analysis can substantially reduce the volume of blood needed and, therefore, presents a particular opportunity for reducing animal use in s...

BACKGROUND Poor quality dried blood spot (DBS) specimens are usually rejected by virology laboratories, affecting early infant diagnosis of HIV. The practice of combining two incompletely-filled DBS in one specimen preparation tube during pre-analytical specimen processing (i.e., the two-spot method) has been implemented to reduce the number of specimens being rejected for insufficient volume. ...

BACKGROUND Vitamin A deficiency is an important dietary deficiency in the world. Thus, the ne¬cessity of screening for deficient populations is obvious. This paper introduces a fast, cheap and relatively reliable method called "dried blood spot" (DBS) method in screening the deficient populations. The validity of this method for retinol measurement was investigated. METHOD The "precision" and...

Drug control policies and interventions, like any other policies and interventions, generate many unintended consequences. Most often, such consequences are mentioned without being defined or presented in a typology and they are rarely explained in terms of causality. This paper will stress how the existing work on the unintended consequences of drug control policies and interventions suffers f...

This study evaluates the nutritional value of several species of freeze-dried microalgae used to feed the seed of Ruditapes decussatus. These microalgae were: Isochrysis galbana, clone T-ISO; Tetraselmis suecica; and Phaeodactylum tricornutum. The addition of antibiotics, kaolin and fresh microalgae to the freeze-dried diet was also evaluated, and a study was made of the nutritional value of on...

In this study, the effect of drying procedure on the pigment levels of three traditionally used medicinal plants were determined and the contribution of the pigment compounds to the overall biological potential of these plant species was examined. The contents of total phenols, anthocyanins, carotenoids and chlorophylls a and b were determined spectrophotometrically, in fresh lemon balm (Meliss...

Rate and efficiency of gain were not affected by adding as much as 20% distillers dried grains in isocaloric diets for nursery pigs or 30% in isocaloric diets for finishing pigs. These results demonstrate that the previously suggested maximums of 5% distillers dried grains in nursery diets and 10% distillers dried grains in finishing diets are too conservative. Finally, because the 20% (nursery...

Food and agriculture commodity boards have become important funders of nutrition research. There are benefits and cautions (biases toward health benefits, failure to publish negative results, and aggressive promotion of single studies) for this activity. The California Dried Plum Board, along with other commodity boards, have developed independent Scientific Nutrition Advisory Panels to guide a...

Described is an evaluation of the card agglutination test (Testryp CATT) applied to dried blood collected on filter-paper. The sensitivity of the test was compared for samples of diluted sera, whole blood and dried blood. Sera diluted 1:8 gave similar CATT results to those obtained with dried blood. The false negative rate was 5.8%, and test specificity, 100.0%. Use of CATT with samples of drie...

Two studies were conducted to evaluate the effects of spray-dried blood meal and its pH on nursery pig performance. Spray-dried blood meal pH decreases as storage time increases prior to spray drying. In Exp. 1, addition of 2.5% spray-dried blood meal to the diet improved ADG and ADFI in nursery pigs (15.4 lb to 35.9 lb), but did not influence feed efficiency. In Exp. 2, the inclusion of 5% spr...