BACKGROUND This study was performed to evaluate the diagnostic accuracy of a pharmacovigilance algorithm in patients with 1 or more histories suggestive of drug hypersensitivity. METHODS We performed a retrospective analysis of a clinic case series. We analyzed patients with suspected clinical reactions of drug hypersensitivity. Patients with severe skin reactions were excluded. Patients with...

Hypersensitivity to drugs is a complex diagnostic challenge. Detailed medical history remains the mainstay of drug hypersensitivity evaluation, which further determines diagnostic procedures, especially the types of skin tests to be performed. The current paper presents the case of a female patient with coexisting features of supposed immunoglobulin E (IgE) dependent allergic hypersensitivity t...

Betalactam (BL) antibiotics are the most common cause of drug-induced hypersensitivity reactions (DHR). We present 2 clinical cases patients with suspected immediate BL DHR who underwent drug allergy workup according to standardized diagnostic procedures, including skin tests (STs: prick, prick test, and intradermal [IDTs]) provocation (DPTs).1 ST results became positive after first DPT dose. T...

Drug-induced hypersensitivity reactions are of major concern and present a burden for national healthcare systems due to their often severe nature, high rate of hospital admissions and high mortality. They manifest with a wide range of symptoms and signs, and can be initiated by a wide range of structurally diverse chemical compounds. The pathophysiological mechanisms underlying hypersensitivit...