The oseltamivir has also been recommended in Iran in the annex to the "National Guidelines for novel Coronavirus" and in the prime version of the Flowchart of Diagnosis and Treatment of COVID 19 at the outpatient and inpatient levels .The oseltamivir (Tamiflu) is a neuraminidase inhibitor that blocks the release of flu virus-laden droplets from infected cells in the respiratory tract. The oselt...

In addition to increasing the efficacy of various drugs, Nanoparticles reduce their side effects. In this study, different nanoparticle formulations of Doxorubicin anticancer drugs were prepared. The efficacy of the formulations produced in the cell culture medium was studied compared with the free drug. Reverse phase evaporation was used to form the liposome containing do...

A new quantitative index is proposed to assign a numerical value that reflects the compromise between the therapeutic and side effects during treatment of AIDS using drugs that are active against HIV. The model considers that the clinical conditions are related to the values of CD4T cell counts and viral load. The therapeutic effect is associated with increase in the CD4T cell counts, while the...

introduction: patients referred to as having thalassemia major are usually those who come to medical attention in the first year of life and subsequently require regular transfusions to survive. those who present later or who seldom need transfusions are said to have thalassemia intermediahydroxyurea, an s-phase-specific and non-dna-hypomethylating chemotherapeutic agents is capable of inducing...

drug induced dystonic reactions are among common presentations of patients in emergency departments, and typically occur with antidopaminergic agents as their extra-pyramidal side effects. dystonic reactions usually occur within the first few hours or days after commencing a drug or dose increase. unlike other extra-pyramidal side effects, a patient may experience acute dystonic reactions (adrs...

objective:  unaccustomed and intense eccentric exercise is a common cause of delayed-onset muscle soreness (doms). there are multiple remedies for the treatment of doms, but its clinical and laboratory pieces of evidence are scarce. currently, the treatments proposed for doms are numerous and include pharmaceuticals, herbal remedies, stretching, massage, nutritional supplements, and other alter...

The optimal management of opioid-related side effects is hampered by a lack of comparative studies of management strategies. The prevalence of such side effects is influenced by the extent of disease, the patient's age, the presence of coexistent renal and hepatic disease, pulmonary disease, and cognitive dysfunction, a prior opioid history, use of polypharmacy, dose of opioid drug being admini...

Thromboembolic disease is a common cause of morbidity and mortality. Thrombin plays a key role in thrombotic events and thrombin inhibition represents a therapeutic event for thromboembolic events and has been identified as a target of therapy of its pivotal role in coagulation process. Anticoagulation is a major intervention for the management of arterial and venous thromboembolic events. Dabi...