Data on the natural history of infants discharged with patent ductus arteriosus is sparse. We report on the 36-months follow-up after hospitalization in 68 infants discharged with an open ductus arteriosus. Notwithstanding a high spontaneous closure rate, catheter intervention in 5 infants illustrates a critical need for cardiologic follow-up.

Isolated mycotic saccular aneurysm of the left pulmonary artery as a result of acute bacterial endarteritis complicating persistent ductus arteriosus is described in 2 children aged I3 years and 7 years. Successful resection of the aneurysm was accomplished in the first child. The second child had associated aortic incompetence and succumbed from cardiac failure while awaiting operation. Aneury...

Duration of ductal shunting in healthy preterm infants: an echocardiographic color flow Doppler study. Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation. Re-evaluation of the left atrial to aortic root ratio as a marker of patent ductus arteriosus. Selective head cooling with mild systemic hypothermia after neonatal e...

Introduction Ibuprofen is used widely to close patent ductus arteriosus in preterm infants. The anti-inflammatory activity of ibuprofen may also be partly due to its ability to scavenge reactive oxygen species and reactive nitrogen species. We evaluated the interaction between oxidative status and the medical treatment of patent ductus arteriosus with two forms of ibuprofen. Materials and metho...

INTRODUCTION Restoration of blood flow through a previously occluded ductus arteriosus may occur in some patients. Treatment strategy in patients with such residual shunts has not yet been uniformly established. AIM To present single-centre experience and to attempt to establish a strategy of management of patients with residual ductus arteriosus shunts following percutaneous closure. METHO...

background: closure of patent ductus arteriosus (pda), ventricular septal defect (vsd) and atrial septal defect (asd) can be done surgically or by device. this study was designed to compare the total cost of surgical or device closures of pda, asd or vsd for iranian patients. methods: this is a cross-sectional study, conducted from january 1, 2005 until january 1, 2006 in two large heart center...

The classic findings of a patent ductus arteriosus in a young individual are familiar to most physicians. However, it has been appreciated that several factors, principally pulmonary hypertension or pulmonary artery dilatation in the absence of appreciable hypertension, may significantly alter the classic image and lead to the erroneous diagnosis of ventricular septal defect. In 10 surgically p...

The diagnosis of patent ductus arteriosus is difficult when the classic continuous murmur is not present. In infancy, in the presence of cardiac decompensation and when the ductus approximates the aorta in size, the continuous murmur is frequently absent. A correct diagnosis may be important, however, for a large patent ductus arteriosus can cause serious difficulty. Early surgical treatment ma...

The physiological role of endothelin-1 (ET-1) in regulation of vascular tone in the perinatal lung is controversial. Recent studies suggest that ET-1 contributes to high basal pulmonary vascular resistance in the normal fetus, but its role in the modulation of pulmonary vascular tone remains uncertain. We hypothesized that high ET-1 activity opposes the vasodilator response to some physiologica...

The diagnosis of patent ductus arteriosus is difficult when the classic continuous murmur is not present. In infancy, in the presence of cardiac decompensation and when the ductus approximates the aorta in size, the continuous murmur is frequently absent. A correct diagnosis may be important, however, for a large patent ductus arteriosus can cause serious difficulty. Early surgical treatment ma...