Purpose: RNA interference has the potential to specifically knockdown the expression of target genes and thereby transform cancer therapy. However, lack of effective delivery of siRNA has dramatically limited its in vivo applications. We have developed a multistage vector (MSV) system, composed of discoidal porous silicon particles loaded with nanotherapeutics, that directs effective delivery a...

Microalgae and cyanobacteria are rich sources of numerous phytochemical compounds with intrinsic antifungal potential. This research aimed to screen the contents, as well antioxidant profiles, in eight cyanobacterial two microalgal strains isolated from soil brackish water habitats Egypt. Our study also evaluated their activities against three phytopathogenic fungi—namely, Pythium ultimum, Fusa...

Maize streak virus (MSV; family Geminiviridae, genus Mastrevirus), the causal agent of maize streak disease, ranks amongst the most serious biological threats to food security in subSaharan Africa. Although five distinct MSV strains have been currently described, only one of these - MSV-A - causes severe disease in maize. Due primarily to their not being an obvious threat to agriculture, very l...

The aim of this paper is to analyze the current evidence on radiocerebral effects following exposure to <5 Sv. Dose-related cognitive and neurophysiological abnormalities among prenatally exposed children after the Chernobyl accident at gestation ages of +8 weeks were revealed at >20 mSv on the fetus and >300 mSv on the thyroid in utero; at 16–25 weeks, abnormalities were >10 mSv and >200 mSv, ...

This pathway provides guidance for imaging adult patients with blunt abdominal trauma. The initial steps depend on the haemodynamic stability of the patient. Date reviewed: August 2013 Date of next review: 2017/2018 Published: August 2013 Quick User Guide Move the mouse cursor over the PINK text boxes inside the flow chart to bring up a pop up box with salient points. Clicking on the PINK text ...

This pathway provides guidance on the investigation of patients with symptoms and / or signs of suspected colorectal cancer. Date reviewed: December 2015 Date of next review: December 2018 Published: August 2016 Quick User Guide Move the mouse cursor over the PINK text boxes inside the flow chart to bring up a pop up box with salient points. Clicking on the PINK text box will bring up the full ...

This pathway provides guidance for imaging adult trauma patients with suspected injuries to their lower urinary tract. Date reviewed: August 2013 Date of next review: 2017/2018 Published: August 2013 Quick User Guide Move the mouse cursor over the PINK text boxes inside the flow chart to bring up a pop up box with salient points. Clicking on the PINK text box will bring up the full text. The re...

This pathway provides guidance on imaging patients with proven colorectal cancer, indicating how imaging helps determine management. Date reviewed: January 2012 Date of next review: 2017/2018 Published: January 2012 Quick User Guide Move the mouse cursor over the PINK text boxes inside the flow chart to bring up a pop up box with salient points. Clicking on the PINK text box will bring up the f...

This pathway provides a staging algorithm for patients with proven gastric cancer, indicating how imaging helps determine management. Date reviewed: March 2015 Date of next review: 2017/2018 Published: July 2015 Quick User Guide Move the mouse cursor over the PINK text boxes inside the flow chart to bring up a pop up box with salient points. Clicking on the PINK text box will bring up the full ...

This pathway provides guidance on the staging of adult patients with laryngeal cancer, prior to definitive treatment. Date reviewed: January 2012 Date of next review: 2017/2018 Published: January 2012 Quick User Guide Move the mouse cursor over the PINK text boxes inside the flow chart to bring up a pop up box with salient points. Clicking on the PINK text box will bring up the full text. The r...